Association between obesity and combination antiretroviral therapy (cART) adherence among persons with early-stage HIV infection initiating cART.
Journal
International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
02
10
2020
accepted:
23
04
2021
revised:
23
03
2021
pubmed:
20
5
2021
medline:
29
1
2022
entrez:
19
5
2021
Statut:
ppublish
Résumé
Obesity is common among people living with HIV (PLWH) and early-stage infection, yet associations with combination antiretroviral (cART) adherence are unclear. Among PLWH initiating cART in Uganda and South Africa, body mass index (BMI) was assessed at cART initiation, and cART adherence was monitored in real-time over 12 months. The association of obesity (BMI ≥ 30 kg/m Among 322 participants, median age was 32 years, 70% were female, and 54% were from Uganda. Prevalence of obesity was 12% in Uganda and 28% in South Africa. Mean overall cART adherence was 83% in Uganda and 66% in South Africa. Participants with obesity had higher adherence than those without obesity: +3.6% (p = 0.44) in Uganda and +11.4% (p = 0.02) in South Africa. Obesity at cART initiation was common and associated with higher adherence, although only significantly in South Africa.
Sections du résumé
BACKGROUND
Obesity is common among people living with HIV (PLWH) and early-stage infection, yet associations with combination antiretroviral (cART) adherence are unclear.
METHODS
Among PLWH initiating cART in Uganda and South Africa, body mass index (BMI) was assessed at cART initiation, and cART adherence was monitored in real-time over 12 months. The association of obesity (BMI ≥ 30 kg/m
RESULTS
Among 322 participants, median age was 32 years, 70% were female, and 54% were from Uganda. Prevalence of obesity was 12% in Uganda and 28% in South Africa. Mean overall cART adherence was 83% in Uganda and 66% in South Africa. Participants with obesity had higher adherence than those without obesity: +3.6% (p = 0.44) in Uganda and +11.4% (p = 0.02) in South Africa.
CONCLUSION
Obesity at cART initiation was common and associated with higher adherence, although only significantly in South Africa.
Identifiants
pubmed: 34007011
doi: 10.1038/s41366-021-00837-y
pii: 10.1038/s41366-021-00837-y
pmc: PMC8316269
mid: NIHMS1697167
doi:
Substances chimiques
Anti-Retroviral Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1855-1859Subventions
Organisme : NICHD NIH HHS
ID : K23 HD097300
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH114732
Pays : United States
Organisme : NIDDK NIH HHS
ID : L30 DK118710
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK040561
Pays : United States
Investigateurs
Bosco M Bwana
(BM)
Gideon Amanyire
(G)
Lynn T Matthews
(LT)
Alexander C Tsai
(AC)
Ingrid T Katz
(IT)
Kathleen Bell
(K)
Annet Kembabazi
(A)
Stephen Mugisha
(S)
Victoria Kibirige
(V)
Anna Cross
(A)
Nicola Kelly
(N)
Bethany Hedt-Gauthier
(B)
David R Bangsberg
(DR)
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
Références
Collaborators GBDO, Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377:13–27.
doi: 10.1056/NEJMoa1614362
WHO. Global Health Observatory (GHO) data. https://www.who.int/data/gho/data/indicators/indicator-details/GHO/prevalence-ofoverweight-among-adults-bmi-=-25-(age-standardized-estimate)-(-) .
Guehi C, Badje A, Gabillard D, Ouattara E, Koule SO, Moh R, et al. High prevalence of being Overweight and Obese HIV-infected persons, before and after 24 months on early ART in the ANRS 12136 Temprano Trial. AIDS Res Ther. 2016;13:12.
doi: 10.1186/s12981-016-0094-y
WHO. HIV/AIDS. In: Key facts; 2019.
Coetzee L, Bogler L, De Neve JW, Barnighausen T, Geldsetzer P, Vollmer S. HIV, antiretroviral therapy and non-communicable diseases in sub-Saharan Africa: empirical evidence from 44 countries over the period 2000 to 2016. J Int AIDS Soc. 2019;22:e25364.
doi: 10.1002/jia2.25364
Biggs C, Spooner E. Obesity and HIV: a compounding problem. South Afr J Clin Nutr. 2018;31:78–83.
doi: 10.1080/16070658.2017.1404299
Bailin SS, Gabriel CL, Wanjalla CN, Koethe JR. Obesity and weight gain in persons with HIV. Curr HIV/AIDS Rep. 2020;17:138–150.
doi: 10.1007/s11904-020-00483-5
Venter WDF, Moorhouse M, Sokhela S, Fairlie L, Mashabane N, Masenya M, et al. Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV. N Engl J Med. 2019;381:803–815.
doi: 10.1056/NEJMoa1902824
Kumar S, Samaras K. The impact of weight gain during HIV treatment on risk of pre-diabetes, diabetes mellitus, cardiovascular disease, and mortality. Front Endocrinol. 2018;9:705.
doi: 10.3389/fendo.2018.00705
Haberer JE, Bwana BM, Orrell C, Asiimwe S, Amanyire G, Musinguzi N, et al. ART adherence and viral suppression are high among most non-pregnant individuals with early-stage, asymptomatic HIV infection: an observational study from Uganda and South Africa. J Int AIDS Soc. 2019;22:e25232.
doi: 10.1002/jia2.25232
Mayega RW, Etajak S, Rutebemberwa E, Tomson G, Kiguli J. ‘Change means sacrificing a good life’: perceptions about severity of type 2 diabetes and preventive lifestyles among people afflicted or at high risk of type 2 diabetes in Iganga Uganda. BMC Public Health. 2014;14:864.
doi: 10.1186/1471-2458-14-864
Lambert RF, Orrell C, Bangsberg DR, Haberer JE. Factors that motivated otherwise healthy HIV-positive young adults to access HIV testing and treatment in South Africa. AIDS Behav. 2018;22:733–741.
doi: 10.1007/s10461-017-1704-y
Zheng W, McLerran DF, Rolland B, Zhang X, Inoue M, Matsuo K, et al. Association between body-mass index and risk of death in more than 1 million Asians. N Engl J Med. 2011;364:719–729.
doi: 10.1056/NEJMoa1010679
Manne-Goehler J, Baisley K, Vandormael A, Bärnighausen T, Tanser F, Herbst K, et al. BMI and All-Cause Mortality in a Population-Based Cohort in Rural South Africa. Obesity. 2020;28:2414–23. https://doi.org/10.1002/oby.23005 .
doi: 10.1002/oby.23005
pubmed: 33070472
Heerden Iv. Mieliepap (maize meal porridge) and the glycaemic index. Health. 2013;24. https://www.health24.com/Diet-and-nutrition/Nutrition-basics/Mieliepap-maize-meal-porridge-and-the-glycaemic-index-20130210 .
Tsai AC, Bangsberg DR, Emenyonu N, Senkungu JK, Martin JN, Weiser SD. The social context of food insecurity among persons living with HIV/AIDS inrural Uganda. Soc Sci Med 2011,73:1717–24.
Bolton P, Wilk CM, Ndogoni L. Assessment of depression prevalence in rural Uganda using symptom and function criteria. Soc Psychiatry Psychiatr Epidemiol 2004,39:442–7.
Bradley KA, DeBenedetti AF, Volk RJ, Williams EC, Frank D, Kivlahan DR. AUDIT-C as a brief screen for alcohol misuse in primary care. Alcohol Clin Exp Res 2007,31:1208–17.
Jeyaseelan L, Kumar S, Mohanraj R, Rebekah G, Rao D, Manhart LE. Assessing HIV/AIDS stigma in south India: validation and abridgement of the Berger HIV Stigma scale. AIDS Behav 2013,17:434–43.