Targeted inhibition of STAT3 in neural stem cells promotes neuronal differentiation and functional recovery in rats with spinal cord injury.
STAT3
neural stem cells
neuronal differentiation
spinal cord injury
Journal
Experimental and therapeutic medicine
ISSN: 1792-0981
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
19
09
2020
accepted:
02
02
2021
entrez:
19
5
2021
pubmed:
20
5
2021
medline:
20
5
2021
Statut:
ppublish
Résumé
STAT3 is expressed in neural stem cells (NSCs), where a number of studies have previously shown that STAT3 is involved in regulating NSC differentiation. However, the possible molecular mechanism and role of STAT3 in spinal cord injury (SCI) remain unclear. In the present study, the potential effect of STAT3 in NSCs was first investigated by using short hairpin RNA (shRNA)-mediated STAT3 knockdown in rat NSCs
Identifiants
pubmed: 34007320
doi: 10.3892/etm.2021.10143
pii: ETM-0-0-10143
pmc: PMC8120646
doi:
Types de publication
Journal Article
Langues
eng
Pagination
711Informations de copyright
Copyright: © Li et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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