Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
09
2020
revised:
30
03
2021
accepted:
13
04
2021
entrez:
19
5
2021
pubmed:
20
5
2021
medline:
16
11
2021
Statut:
epublish
Résumé
The aim of the present study was to investigate the protective effects and mechanisms of KLK1 on aging-related prostate alterations and search clues about the application of KLK1 to the treatment of human BPH. Thirty-six rats including 26 male wild-type SD rats and 10 transgenic rats were fed to 3- or 18-month-old and divided into three groups: young WTR (yWTR) as the control ( The human KLK1 gene only existed and was expressed in aTGR. The prostate of young rats expressed more KLK1 than the aged and the expression of KLK1 in prostate decreased with age in humans ( KLK1 protects prostate from oxidative stress and fibrosis via amplified NO/cGMP signal in aged rats. The decrease of KLK1 expression with aging is laying the groundwork for the application of KLK1 to the treatment of human BPH. The current experimental data showed that the side effects of KLK1 on the prostate cell were not obvious.
Identifiants
pubmed: 34007408
doi: 10.1155/2021/8877540
pmc: PMC8110393
doi:
Substances chimiques
Antioxidants
0
Tissue Kallikreins
EC 3.4.21.35
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8877540Informations de copyright
Copyright © 2021 Mengyang Zhang et al.
Déclaration de conflit d'intérêts
All authors report no conflicts of interest.
Références
PLoS One. 2017 Jan 19;12(1):e0170427
pubmed: 28103290
J Cell Biochem. 2019 Aug;120(8):14127-14135
pubmed: 31020704
Prostate. 2015 Oct;75(14):1643-61
pubmed: 26184673
Yale J Biol Med. 2020 Mar 27;93(1):175-185
pubmed: 32226346
Acta Cir Bras. 2020 Jun 19;35(4):e202000402
pubmed: 32578722
Cell Mol Life Sci. 2008 Jul;65(13):2019-38
pubmed: 18344018
World J Urol. 2020 Nov;38(11):2933-2943
pubmed: 31965289
Biomed Res Int. 2015;2015:304753
pubmed: 25918708
J Sex Med. 2016 Sep;13(9):1311-1322
pubmed: 27555503
Ther Adv Neurol Disord. 2019 Jan 20;12:1756286418821918
pubmed: 30719079
Asian J Androl. 2017 Jan-Feb;19(1):67-72
pubmed: 27678468
Cytoskeleton (Hoboken). 2010 Sep;67(9):545-54
pubmed: 20803696
Eur J Pharmacol. 2001 Oct 19;429(1-3):161-76
pubmed: 11698039
Endocrinology. 2010 Aug;151(8):3975-84
pubmed: 20555034
Biol Chem. 2010 Apr;391(4):345-55
pubmed: 20180644
Int J Mol Med. 2018 Mar;41(3):1177-1186
pubmed: 29328364
Br J Pharmacol. 2004 May;142(2):297-304
pubmed: 15155537
J Urol. 1992 May;147(5):1293-7
pubmed: 1373778
Exp Gerontol. 2000 Dec;35(9-10):1267-79
pubmed: 11113607
Curr Aging Sci. 2021 Feb 02;:
pubmed: 33535964
J Pathol. 2001 Dec;195(5):571-9
pubmed: 11745693
Sex Med Rev. 2019 Apr;7(2):259-271
pubmed: 30803920
Peptides. 1991 Sep-Oct;12(5):1057-62
pubmed: 1724795
Hypertension. 1998 Jul;32(1):84-8
pubmed: 9674642
Life Sci. 2008 Jan 16;82(3-4):156-65
pubmed: 18068196
Afr Health Sci. 2014 Sep;14(3):657-62
pubmed: 25352885
FASEB J. 2006 May;20(7):916-25
pubmed: 16675849
Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1462-4
pubmed: 21677286
Endocrinology. 1996 Mar;137(3):864-72
pubmed: 8603596
J Biol Chem. 1997 Dec 26;272(52):32773-8
pubmed: 9407051
J Cell Sci. 2003 Sep 1;116(Pt 17):3645-55
pubmed: 12876216
Curr Urol Rep. 2019 Aug 3;20(9):54
pubmed: 31377881
FASEB J. 2000 Oct;14(13):1858-60
pubmed: 11023967
PLoS One. 2014 Oct 02;9(10):e109102
pubmed: 25275645
FEBS J. 2009 Jun;276(11):2947-65
pubmed: 19490100
Cardiovasc Res. 2009 Aug 1;83(3):511-8
pubmed: 19406912
Hypertension. 2004 Aug;44(2):230-5
pubmed: 15249543
Circ Res. 2010 Jun 11;106(11):1675-80
pubmed: 20538689
Postepy Hig Med Dosw (Online). 2017 Jan 28;71(0):57-68
pubmed: 28181912
Aging (Albany NY). 2019 May 13;11(9):2653-2669
pubmed: 31085797
Growth Factors. 2011 Oct;29(5):196-202
pubmed: 21740331
Eur J Pharmacol. 2004 Nov 19;504(3):155-67
pubmed: 15541417
Nat Rev Urol. 2016 Sep 30;13(10):613-26
pubmed: 27686153
Peptides. 2015 Nov;73:7-19
pubmed: 26256678
Indian J Urol. 2014 Apr;30(2):170-6
pubmed: 24744516
Expert Opin Pharmacother. 2019 Jun;20(8):929-937
pubmed: 30901259
Oxid Med Cell Longev. 2012;2012:458276
pubmed: 23150749