Hemorrhagic Shock after Neonatal Circumcision: Severe Congenital Factor XIII Deficiency.
Journal
Case reports in pediatrics
ISSN: 2090-6803
Titre abrégé: Case Rep Pediatr
Pays: United States
ID NLM: 101581030
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
01
2021
revised:
22
04
2021
accepted:
22
04
2021
entrez:
19
5
2021
pubmed:
20
5
2021
medline:
20
5
2021
Statut:
epublish
Résumé
A Caucasian male infant born full term via normal spontaneous vaginal delivery was given vitamin K after birth, circumcised on day of life (DOL) 1, and discharged from the nursery on DOL 2. At the time of circumcision, oozing from the surgical site was noted and initially resolved with silver nitrate. Over the next two days, he presented to local emergency rooms multiple times for recurrent bleeding, eventually developing hemorrhagic shock resulting in admission to the neonatal intensive care unit. After extensive work up, he was ultimately diagnosed with severe congenital factor XIII deficiency. Congenital factor XIII deficiency is a rare bleeding disorder characterized by normal prothrombin time (PT) and activated partial thromboplastin time (aPTT) coagulation labs on routine screening, and has a high risk of complications, such as spontaneous intracranial hemorrhage. Although uncommon, when caring for a child with bleeding, physicians must have a high index of suspicion to make this diagnosis in order to initiate proper treatment and start prophylaxis given the risk of morbidity and mortality in untreated patients.
Identifiants
pubmed: 34007504
doi: 10.1155/2021/5550199
pmc: PMC8110377
doi:
Types de publication
Case Reports
Langues
eng
Pagination
5550199Informations de copyright
Copyright © 2021 Erin L. Cohen et al.
Déclaration de conflit d'intérêts
The authors declare they have no conflicts of interest.
Références
J Thromb Haemost. 2012 Apr;10(4):615-21
pubmed: 22321862
Blood Rev. 2016 Nov;30(6):461-475
pubmed: 27344554
J Thromb Haemost. 2017 Aug;15(8):1601-1606
pubmed: 28581691
Pediatrics. 2002 Feb;109(2):E32
pubmed: 11826242
Int J Lab Hematol. 2018 Feb;40(1):3-11
pubmed: 29027765
Blood Rev. 2017 Jan;31(1):37-45
pubmed: 27542511
Transfus Med Hemother. 2016 Sep;43(5):365-373
pubmed: 27781024
Haemophilia. 2008 Nov;14(6):1255-60
pubmed: 19141166
Arch Dis Child Fetal Neonatal Ed. 1999 May;80(3):F238-9
pubmed: 10212091
Haemophilia. 2013 Nov;19(6):814-26
pubmed: 23607876
J Coll Physicians Surg Pak. 2008 Sep;18(9):565-8
pubmed: 18803895
Pediatrics. 2013 Nov;132(5):882-92
pubmed: 24127475
J Thromb Haemost. 2011 Jul;9(7):1404-6
pubmed: 22946956
Haemophilia. 2008 Nov;14(6):1250-4
pubmed: 19141165
Physiol Rev. 2011 Jul;91(3):931-72
pubmed: 21742792
Transfusion. 2009 Apr;49(4):765-70
pubmed: 19192257
J Thromb Haemost. 2003 Aug;1(8):1852-3
pubmed: 12911609
Int J Hematol. 2014 Nov;100(5):443-9
pubmed: 25230816
Arch Pathol Lab Med. 2014 Feb;138(2):278-81
pubmed: 24476525
Haemophilia. 2008 Nov;14(6):1190-200
pubmed: 19141159
Br J Haematol. 2020 Jan;188(2):317-320
pubmed: 31414482
Saudi Med J. 2002 May;23(5):552-4
pubmed: 12070580
Blood. 1987 Jul;70(1):165-72
pubmed: 3593964