Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin.
Adenocarcinoma
/ pathology
Aged
Ampulla of Vater
/ pathology
Bile Ducts
/ pathology
Common Bile Duct Neoplasms
/ pathology
Female
Humans
Male
Neoplasms, Unknown Primary
/ pathology
Pancreatectomy
Pancreatic Ducts
/ pathology
Pancreatic Neoplasms
/ pathology
Prospective Studies
Surveys and Questionnaires
/ statistics & numerical data
ampulla of Vater carcinoma
distal bile duct carcinoma
indeterminable tumor primary
pancreatic ductal adenocarcinoma
periampullary region
Journal
Cancer medicine
ISSN: 2045-7634
Titre abrégé: Cancer Med
Pays: United States
ID NLM: 101595310
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
10
01
2021
accepted:
09
02
2021
pubmed:
20
5
2021
medline:
18
12
2021
entrez:
19
5
2021
Statut:
ppublish
Résumé
Determination of the primary tumor in periampullary region carcinomas can be difficult, and the pathological assessment and clinicopathological characteristics remain elusive. In this study, we investigated the current recognition and practices for periampullary region adenocarcinoma with an indeterminable origin among expert pathologists through a cognitive survey. Simultaneously, we analyzed a prospective collection of cases with an indeterminable primary tumor diagnosed from 2008 to 2018 to elucidate their clinicopathological features. All cases with pathological indeterminable primary tumors were reported and discussed in a clinicopathological conference to elucidate if it was possible to distinguish the primary tumor clinically and pathologically. From the cognitive survey, over 85% of the pathologists had experienced cases with indeterminable primary tumors; however, 70% of the cases was reported as pancreatic cancer without definitive grounds. Interpretation of the main tumor mass varied, and no standardized method was developed to determine the primary tumor. During a prospective study, 42 of the 392 periampullary carcinoma cases (10.7%) were considered as tumors with a pathological indeterminable origin. After the clinicopathological conferences, 21 (5.4%) remained indeterminable and were considered final indeterminable cases. Histological studies showed that the tumors spread along both the bile duct and main pancreatic duct; this was the most representative finding of the final indeterminable cases. This study is the first to elucidate and recognize the current clinicopathological features of periampullary region adenocarcinomas with an indeterminable origin. Adequate assessment of primary tumors in periampullary region carcinomas will help to optimize epidemiological data of pancreatic and bile duct cancer.
Identifiants
pubmed: 34008914
doi: 10.1002/cam4.3809
pmc: PMC8178491
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3499-3510Informations de copyright
© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
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