Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice.
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
entrez:
19
5
2021
pubmed:
20
5
2021
medline:
24
11
2021
Statut:
ppublish
Résumé
Exposure to secondhand smoke (SHS) is a risk factor for developing sporadic forms of sporadic dementia. A human tau (htau) mouse model is available that exhibits age-dependent tau dysregulation, neurofibrillary tangles, neuronal loss, neuroinflammation, and oxidative stress starting at an early age (3-4 months) and in which tau dysregulation and neuronal loss correlate with synaptic dysfunction and cognitive decline. The goal of this study was to assess the effects of chronic SHS exposure (10 months' exposure to Wild-type (WT) and htau female and male mice were exposed to SHS (90% side stream, 10% main stream) using the SCIREQ® inExpose™ system or air control for 168 min per day, for 312 d, 7 d per week. The exposures continued during the days of behavioral and cognitive testing. In addition to behavioral and cognitive performance and neuropathology, the lungs of mice were examined for pathology and alterations in gene expression. Mice exposed to chronic SHS exposure showed the following genotype-dependent responses: The brain of WT mice, in particular WT male mice, might be especially susceptible to the effects of chronic SHS exposure. In WT males, independent pathways involving ascorbate, flavin adenine dinucleotide, or palmitoleic acid might contribute to the hippocampal injury following chronic SHS exposure. https://doi.org/10.1289/EHP8428.
Sections du résumé
BACKGROUND
Exposure to secondhand smoke (SHS) is a risk factor for developing sporadic forms of sporadic dementia. A human tau (htau) mouse model is available that exhibits age-dependent tau dysregulation, neurofibrillary tangles, neuronal loss, neuroinflammation, and oxidative stress starting at an early age (3-4 months) and in which tau dysregulation and neuronal loss correlate with synaptic dysfunction and cognitive decline.
OBJECTIVE
The goal of this study was to assess the effects of chronic SHS exposure (10 months' exposure to
METHODS
Wild-type (WT) and htau female and male mice were exposed to SHS (90% side stream, 10% main stream) using the SCIREQ® inExpose™ system or air control for 168 min per day, for 312 d, 7 d per week. The exposures continued during the days of behavioral and cognitive testing. In addition to behavioral and cognitive performance and neuropathology, the lungs of mice were examined for pathology and alterations in gene expression.
RESULTS
Mice exposed to chronic SHS exposure showed the following genotype-dependent responses:
DISCUSSION
The brain of WT mice, in particular WT male mice, might be especially susceptible to the effects of chronic SHS exposure. In WT males, independent pathways involving ascorbate, flavin adenine dinucleotide, or palmitoleic acid might contribute to the hippocampal injury following chronic SHS exposure. https://doi.org/10.1289/EHP8428.
Identifiants
pubmed: 34009016
doi: 10.1289/EHP8428
pmc: PMC8132614
doi:
Substances chimiques
Tobacco Smoke Pollution
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
57009Subventions
Organisme : NIA NIH HHS
ID : F31 AG067629
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES030287
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES027943
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG055378
Pays : United States
Références
Tob Control. 2013 May;22(3):164-71
pubmed: 22940677
Neurodegener Dis. 2014;13(2-3):151-3
pubmed: 24029627
Front Pharmacol. 2016 Oct 25;7:391
pubmed: 27826243
Am J Clin Nutr. 2003 Jan;77(1):167-72
pubmed: 12499337
Bioinformatics. 2010 Sep 15;26(18):2342-4
pubmed: 20628077
Neurosci Biobehav Rev. 2014 Jul;44:195-205
pubmed: 23545330
Neurology. 2003 Jun 10;60(11):1777-81
pubmed: 12796530
Front Neurosci. 2019 Dec 13;13:1274
pubmed: 31920473
FASEB J. 2018 Jun 15;:fj201701381
pubmed: 29906247
Ann Clin Transl Neurol. 2017 Mar 01;4(4):226-235
pubmed: 28382304
J Addict. 2013;2013:160486
pubmed: 24804137
Psychopharmacology (Berl). 1986;90(1):101-5
pubmed: 3094051
Dis Model Mech. 2012 May;5(3):333-41
pubmed: 22279084
Acta Neuropathol Commun. 2017 Jul 31;5(1):58
pubmed: 28760159
Nat Commun. 2020 Jan 16;11(1):319
pubmed: 31949159
Metab Brain Dis. 2016 Jun;31(3):497-515
pubmed: 26883429
Ageing Res Rev. 2017 May;35:176-199
pubmed: 27771474
Alzheimers Dement. 2012 Nov;8(6):590-5
pubmed: 22197095
Eur J Nucl Med Mol Imaging. 2020 Nov 19;:
pubmed: 33215319
Front Neurosci. 2017 Apr 24;11:201
pubmed: 28484365
Neuroscience. 2006;137(2):413-23
pubmed: 16330151
J Alzheimers Dis. 2015;50(2):373-86
pubmed: 26682684
Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L705-L722
pubmed: 32083945
Eur Respir J. 2005 Jan;25(1):15-22
pubmed: 15640318
JAMA. 1997 Oct 22-29;278(16):1349-56
pubmed: 9343467
Toxicol Sci. 2011 Oct;123(2):471-9
pubmed: 21778470
Brain. 2020 May 1;143(5):1588-1602
pubmed: 32380523
Nat Rev Neurosci. 2004 Nov;5(11):844-52
pubmed: 15496862
JAMA Neurol. 2015 Sep;72(9):1013-20
pubmed: 26214150
Nat Med. 2020 Aug;26(8):1256-1263
pubmed: 32572268
Behav Brain Res. 1997 Nov;88(2):261-74
pubmed: 9404635
Oncotarget. 2017 Feb 7;8(6):9155-9173
pubmed: 27893434
PLoS One. 2020 Apr 6;15(4):e0230932
pubmed: 32251484
J Cell Commun Signal. 2014 Dec;8(4):293-310
pubmed: 25208934
Respir Res. 2017 Jun 27;18(1):104
pubmed: 28651580
DNA Repair (Amst). 2009 Mar 1;8(3):400-12
pubmed: 19162564
J Neurosci. 2007 Jun 20;27(25):6647-54
pubmed: 17581951
STAR Protoc. 2020 Sep 18;1(2):
pubmed: 33043308
Biochim Biophys Acta. 2013 May;1830(5):3217-66
pubmed: 23036594
Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L743-L756
pubmed: 29351435
Transl Psychiatry. 2013 Dec 03;3:e330
pubmed: 24301648
J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 15;907:117-25
pubmed: 23022114
Diabetes. 2015 Jun;64(6):1933-40
pubmed: 25576061
J Alzheimers Dis. 2015;50(1):133-48
pubmed: 26639972
Sci Rep. 2014 Jan 27;4:3864
pubmed: 24463700
J Pharmacol Exp Ther. 2012 Aug;342(2):568-75
pubmed: 22619254
Sci Rep. 2018 May 10;8(1):7490
pubmed: 29748598
Addiction. 2013 Feb;108(2):420-6
pubmed: 22913297
Environ Health Perspect. 2005 Jan;113(1):98-103
pubmed: 15626655
Environ Res. 2013 Feb;121:64-70
pubmed: 23199696
Front Physiol. 2012 Jul 27;3:300
pubmed: 22934051
J Alzheimers Dis. 2014;38(4):719-40
pubmed: 24072070
PLoS One. 2012;7(5):e36752
pubmed: 22606286
J Neurochem. 2014 Jan;128(2):294-304
pubmed: 24032632
J Alzheimers Dis. 2010;19(2):465-80
pubmed: 20110594
Nat Neurosci. 2014 May;17(5):661-3
pubmed: 24728269
Curr Protoc Toxicol. 2013 May;Chapter 4:Unit4.39
pubmed: 23670865
Exp Mol Med. 2020 Apr;52(4):556-568
pubmed: 32284537
PLoS One. 2017 Mar 31;12(3):e0174354
pubmed: 28362870
Nat Commun. 2013;4:1495
pubmed: 23422663
PLoS One. 2013 May 20;8(5):e63644
pubmed: 23700429
Pharmacol Biochem Behav. 2007 Jan;86(1):32-6
pubmed: 17270256
Acta Neuropathol. 2006 Oct;112(4):471-81
pubmed: 16858608
Tob Control. 2005 Dec;14(6):396-404
pubmed: 16319363
Biochimie. 2015 Mar;110:119-128
pubmed: 25597416
Drug Alcohol Depend. 2017 Mar 01;172:80-87
pubmed: 28157590
J Neurosci. 2016 Dec 7;36(49):12425-12435
pubmed: 27927959
ScientificWorldJournal. 2012;2012:726948
pubmed: 22666146
J Neurosci. 2009 Aug 26;29(34):10741-9
pubmed: 19710325
JAMA Neurol. 2019 May 1;76(5):542-551
pubmed: 30715078
BMJ. 2009 Feb 12;338:b462
pubmed: 19213767
Am J Epidemiol. 2010 Feb 1;171(3):292-302
pubmed: 20051462
Sci Transl Med. 2016 May 11;8(338):338ra66
pubmed: 27169802
Cent Nerv Syst Agents Med Chem. 2014;14(2):113-20
pubmed: 25515716
Front Neurol. 2016 Dec 01;7:215
pubmed: 27990134
Mol Neurobiol. 2012 Dec;46(3):605-13
pubmed: 22886436
Nat Commun. 2020 May 26;11(1):2612
pubmed: 32457389
JAMA. 2014 Dec 17;312(23):2551-61
pubmed: 25514304
Am J Respir Cell Mol Biol. 2008 Aug;39(2):198-207
pubmed: 18367723
Front Mol Neurosci. 2020 Aug 28;13:136
pubmed: 32982685
Curr Dev Nutr. 2017 Nov 15;2(1):1-8
pubmed: 29955721
Front Psychiatry. 2016 Mar 24;7:46
pubmed: 27047401
Nat Commun. 2020 Mar 13;11(1):1382
pubmed: 32170133
Lancet Diabetes Endocrinol. 2015 Dec;3(12):958-67
pubmed: 26388413
Nucleic Acids Res. 2007;35(22):7497-504
pubmed: 17947327
Prev Med. 2019 Jun;123:138-142
pubmed: 30902698