A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression.
MFF
PKD
cell survival
fission
mitochondria
mitosis
mitotic checkpoint
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
18 05 2021
18 05 2021
Historique:
received:
23
07
2020
revised:
26
02
2021
accepted:
22
04
2021
entrez:
19
5
2021
pubmed:
20
5
2021
medline:
10
2
2022
Statut:
ppublish
Résumé
Mitochondria are highly dynamic organelles subjected to fission and fusion events. During mitosis, mitochondrial fission ensures equal distribution of mitochondria to daughter cells. If and how this process can actively drive mitotic progression remains largely unknown. Here, we discover a pathway linking mitochondrial fission to mitotic progression in mammalian cells. The mitochondrial fission factor (MFF), the main mitochondrial receptor for the Dynamin-related protein 1 (DRP1), is directly phosphorylated by Protein Kinase D (PKD) specifically during mitosis. PKD-dependent MFF phosphorylation is required and sufficient for mitochondrial fission in mitotic but not in interphasic cells. Phosphorylation of MFF is crucial for chromosome segregation and promotes cell survival by inhibiting adaptation of the mitotic checkpoint. Thus, PKD/MFF-dependent mitochondrial fission is critical for the maintenance of genome integrity during cell division.
Identifiants
pubmed: 34010649
pii: S2211-1247(21)00468-X
doi: 10.1016/j.celrep.2021.109129
pii:
doi:
Substances chimiques
Mitochondrial Proteins
0
protein kinase D
EC 2.7.10.-
Protein Kinase C
EC 2.7.11.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109129Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.