Stability of the human gut virome and effect of gluten-free diet.

Diet, Gluten-Free / methods Gastrointestinal Microbiome / immunology Humans Virome / immunology
RNA viruses bacteriophage diversity ecosystem resilience gluten gut microbiome viral-like particles virome

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
18 05 2021
Historique:
received: 10 08 2020
revised: 12 01 2021
accepted: 23 04 2021
entrez: 19 5 2021
pubmed: 20 5 2021
medline: 10 2 2022
Statut: ppublish

Résumé

The human gut microbiome consists of bacteria, archaea, eukaryotes, and viruses. The gut viruses are relatively underexplored. Here, we longitudinally analyzed the gut virome composition in 11 healthy adults: its stability, variation, and the effect of a gluten-free diet. Using viral enrichment and a de novo assembly-based approach, we demonstrate the quantitative dynamics of the gut virome, including dsDNA, ssDNA, dsRNA, and ssRNA viruses. We observe highly divergent individual viral communities, carrying on an average 2,143 viral genomes, 13.1% of which were present at all 3 time points. In contrast to previous reports, the Siphoviridae family dominates over Microviridae in studied individual viromes. We also show individual viromes to be stable at the family level but to vary substantially at the genera and species levels. Finally, we demonstrate that lower initial diversity of the human gut virome leads to a more pronounced effect of the dietary intervention on its composition.

Identifiants

DOI: 10.1016/j.celrep.2021.109132 PMID: 34010651
pubmed: 34010651
pii: S2211-1247(21)00471-X
doi: 10.1016/j.celrep.2021.109132
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109132

Subventions

Organisme : Wellcome Trust
ID : 220646/Z/20/Z
Pays : United Kingdom

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Sanzhima Garmaeva (S)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.

Anastasia Gulyaeva (A)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.

Trishla Sinha (T)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.

Andrey N Shkoporov (AN)

APC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 YT20, Ireland.

Adam G Clooney (AG)

APC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 YT20, Ireland.

Stephen R Stockdale (SR)

APC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 YT20, Ireland.

Johanne E Spreckels (JE)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.

Thomas D S Sutton (TDS)

APC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 YT20, Ireland.

Lorraine A Draper (LA)

APC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 YT20, Ireland.

Bas E Dutilh (BE)

Theoretical Biology and Bioinformatics, Science for Life, Utrecht University, Utrecht 3584 CH, the Netherlands.

Cisca Wijmenga (C)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.

Alexander Kurilshikov (A)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.

Jingyuan Fu (J)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.

Colin Hill (C)

APC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 YT20, Ireland.

Alexandra Zhernakova (A)

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands. Electronic address: a.zhernakova@umcg.nl.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Régime sans gluten › Stability of the human gut virome and effect...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Stability of the human gut virome and effect...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Stability of the human gut virome and effect...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Virome › Stability of the human gut virome and effect...