Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.
Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
/ metabolism
CD4-Positive T-Lymphocytes
/ virology
Cell Line, Tumor
G2 Phase Cell Cycle Checkpoints
/ genetics
HEK293 Cells
HIV Infections
/ pathology
HIV-1
/ growth & development
HeLa Cells
Humans
Macrophages
/ virology
Protein Serine-Threonine Kinases
/ genetics
RNA Interference
RNA, Small Interfering
/ genetics
Tandem Mass Spectrometry
Ubiquitin-Protein Ligases
/ genetics
Virus Replication
/ genetics
vpr Gene Products, Human Immunodeficiency Virus
/ genetics
APC1
BioID
HIV infection
Vpr
anaphase-promoting complex/cyclosome
cell cycle regulation
human immunodeficiency virus
proteomics
proximity labeling
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
12 07 2021
12 07 2021
Historique:
pubmed:
21
5
2021
medline:
26
8
2021
entrez:
20
5
2021
Statut:
ppublish
Résumé
HIV-1 encodes several accessory proteins-Nef, Vif, Vpr, and Vpu-whose functions are to modulate the cellular environment to favor immune evasion and viral replication. While Vpr was shown to mediate a G
Identifiants
pubmed: 34011540
pii: JVI.00971-20
doi: 10.1128/JVI.00971-20
pmc: PMC8274603
doi:
Substances chimiques
ANAPC1 protein, human
0
Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
0
RNA, Small Interfering
0
vpr Gene Products, Human Immunodeficiency Virus
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
DCAF1 protein, human
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0097120Subventions
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)
ID : HB2-164064
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