The Marek's Disease Virus Unique Gene MDV082 Is Dispensable for Virus Replication but Contributes to a Rapid Disease Onset.
MDV082
Marek’s disease virus
RLORF11
SORF6
expression kinetics
pathogenesis
tumorigenesis
unique genes
virus replication
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
12 07 2021
12 07 2021
Historique:
pubmed:
21
5
2021
medline:
26
8
2021
entrez:
20
5
2021
Statut:
ppublish
Résumé
Marek's disease virus (MDV) is a highly oncogenic alphaherpesvirus of chickens that causes lymphomas in various organs. Most MDV genes are conserved among herpesviruses, while others are unique to MDV and may contribute to pathogenesis and/or tumor formation. High transcript levels of the MDV-specific genes MDV082, RLORF11, and SORF6 were recently detected in lytically infected cells; however, it remained elusive if the respective proteins are expressed and if they play a role in MDV pathogenesis. In this study, we first addressed if these proteins are expressed by inserting FLAG tags at their N or C termini. We could demonstrate that among the three genes tested, MDV082 is the only gene that encodes a protein and is expressed very late in MDV plaques
Identifiants
pubmed: 34011541
pii: JVI.00131-21
doi: 10.1128/JVI.00131-21
pmc: PMC8274606
doi:
Substances chimiques
Viral Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0013121Commentaires et corrections
Type : ErratumIn
Références
J Exp Med. 2011 Mar 14;208(3):605-15
pubmed: 21383055
Avian Pathol. 2018 Oct;47(5):440-442
pubmed: 29882420
Arch Virol. 1999;144(9):1853-63
pubmed: 10542032
Vet Res. 2010 Sep-Oct;41(5):56
pubmed: 20423696
J Virol. 2019 Aug 13;93(17):
pubmed: 31189706
J Virol. 2014 Jan;88(1):377-92
pubmed: 24155407
J Gen Virol. 2012 Aug;93(Pt 8):1731-1742
pubmed: 22513387
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11603-11607
pubmed: 30337483
J Vet Diagn Invest. 2001 Mar;13(2):162-4
pubmed: 11289214
Vet J. 2005 Sep;170(2):175-83
pubmed: 16129338
Viruses. 2014 Mar 21;6(3):1379-94
pubmed: 24662606
Virology. 2015 Jan 15;475:88-95
pubmed: 25462349
PLoS Pathog. 2011 Oct;7(10):e1002333
pubmed: 22046133
Biotechniques. 2006 Feb;40(2):191-7
pubmed: 16526409
Nat Rev Mol Cell Biol. 2017 Jan;18(1):18-30
pubmed: 27677860
J Virol. 2021 Jan 13;95(3):
pubmed: 33115875
Nat Rev Microbiol. 2006 Apr;4(4):283-94
pubmed: 16541136
Microorganisms. 2019 Nov 20;7(12):
pubmed: 31757008
Viruses. 2019 Mar 16;11(3):
pubmed: 30884829
PLoS Pathog. 2020 Dec 11;16(12):e1009104
pubmed: 33306739
Virology. 2010 Sep 30;405(2):457-63
pubmed: 20637486
Viruses. 2019 Apr 26;11(5):
pubmed: 31027375
Virus Genes. 2008 Apr;36(2):383-92
pubmed: 18266100
Expert Rev Vaccines. 2005 Feb;4(1):77-88
pubmed: 15757475
PLoS Pathog. 2011 Feb;7(2):e1001305
pubmed: 21383974
Poult Sci. 2016 Feb;95(2):375-92
pubmed: 26740135
Viruses. 2019 Jan 28;11(2):
pubmed: 30696089
PLoS Biol. 2021 Apr 26;19(4):e3001057
pubmed: 33901176
J Gen Virol. 2018 Mar;99(3):355-368
pubmed: 29458534
PLoS Pathog. 2010 Aug 26;6(8):e1001073
pubmed: 20865127
Viruses. 2020 Mar 18;12(3):
pubmed: 32197378
Cancers (Basel). 2020 Mar 10;12(3):
pubmed: 32164311
mSphere. 2019 Oct 9;4(5):
pubmed: 31597721
J Biomed Biotechnol. 2012;2012:472537
pubmed: 22496607
J Virol. 2015 Jan 15;89(2):1348-63
pubmed: 25392220