Accuracy of a Deep Learning System for Classification of Papilledema Severity on Ocular Fundus Photographs.

Adolescent Adult Algorithms Databases, Factual Deep Learning Female Fundus Oculi Humans Male Middle Aged Papilledema / diagnosis Severity of Illness Index Young Adult

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
27 07 2021
Historique:
received: 09 11 2020
accepted: 19 04 2021
pubmed: 21 5 2021
medline: 10 8 2021
entrez: 20 5 2021
Statut: ppublish

Résumé

To evaluate the performance of a deep learning system (DLS) in classifying the severity of papilledema associated with increased intracranial pressure on standard retinal fundus photographs. A DLS was trained to automatically classify papilledema severity in 965 patients (2,103 mydriatic fundus photographs), representing a multiethnic cohort of patients with confirmed elevated intracranial pressure. Training was performed on 1,052 photographs with mild/moderate papilledema (MP) and 1,051 photographs with severe papilledema (SP) classified by a panel of experts. The performance of the DLS and that of 3 independent neuro-ophthalmologists were tested in 111 patients (214 photographs, 92 with MP and 122 with SP) by calculating the area under the receiver operating characteristics curve (AUC), accuracy, sensitivity, and specificity. Kappa agreement scores between the DLS and each of the 3 graders and among the 3 graders were calculated. The DLS successfully discriminated between photographs of MP and SP, with an AUC of 0.93 (95% confidence interval [CI] 0.89-0.96) and an accuracy, sensitivity, and specificity of 87.9%, 91.8%, and 86.2%, respectively. This performance was comparable with that of the 3 neuro-ophthalmologists (84.1%, 91.8%, and 73.9%, Our DLS accurately classified the severity of papilledema on an independent set of mydriatic fundus photographs, achieving a comparable performance with that of independent neuro-ophthalmologists. This study provides Class II evidence that a DLS using mydriatic retinal fundus photographs accurately classified the severity of papilledema associated in patients with a diagnosis of increased intracranial pressure.

Identifiants

DOI: 10.1212/WNL.0000000000012226 PMID: 34011570 PMC: PMC8362357
pubmed: 34011570
pii: WNL.0000000000012226
doi: 10.1212/WNL.0000000000012226
pmc: PMC8362357
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e369-e377

Investigateurs

Philippe Gohier (P)
Neil Miller (N)
Tanyatuth Padungkiatsagul (T)
Anuchit Poonyathalang (A)
Yanin Suwan (Y)
Kavin Vanikieti (K)
Giulia Amore (G)
Piero Barboni (P)
Michele Carbonelli (M)
Valerio Carelli (V)
Chiara La Morgia (C)
Martina Romagnoli (M)
Marie-Bénédicte Rougier (MB)
Selvakumar Ambika (S)
Komma Swetha (K)
Pedro Fonseca (P)
Miguel Raimundo (M)
Steffen Hamann (S)
Isabelle Karlesand (I)
Lars Fuhrmann (L)
Sebastian Küchlin (S)
Wolf Alexander Lagrèze (WA)
Nicolae Sanda (N)
Gabriele Thumann (G)
Florent Aptel (F)
Christophe Chiquet (C)
Kaiqun Liu (K)
Hui Yang (H)
Carmen Km Chan (CK)
Noel Cy Chan (NC)
Carol Y Cheung (CY)
Tran Thi Ha Chau (TT)
James Acheson (J)
Maged S Habib (MS)
Neringa Jurkute (N)
Patrick Yu-Wai-Man (P)
Richard Kho (R)
Jost B Jonas (JB)
John J Chen (JJ)
Nouran Sabbagh (N)
Catherine VignalClermont (C)
Rabih Hage (R)
Raoul Kanav Khanna (RK)
Jeong-Min Hwang (JM)
Dong Hyun Kim (DH)
Hee Kyung Yang (HK)
Tin Aung (T)
Ching-Yu Cheng (CY)
Ecosse Lamoureux (E)
Leopold Schmetterer (L)
Zhubo Jiang (Z)
Clare L Fraser (CL)
Luis J Mejico (LJ)
Masoud Aghsaei Fard (MA)

Informations de copyright

© 2021 American Academy of Neurology.

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Auteurs

Caroline Vasseneix (C)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark.
ORCID: 0000-0003-1933-7247

Raymond P Najjar (RP)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark.
ORCID: 0000-0002-3770-2300

Xinxing Xu (X)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark.

Zhiqun Tang (Z)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark.

Jing Liang Loo (JL)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark.

Shweta Singhal (S)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark.
ORCID: 0000-0003-4990-3115

Sharon Tow (S)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark.

Leonard Milea (L)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark. dan.milea@snec.com.sg.

Daniel Shu Wei Ting (DSW)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark.
ORCID: 0000-0003-2264-7174

Yong Liu (Y)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark.

Tien Y Wong (TY)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark.
ORCID: 0000-0002-8448-1264

Nancy J Newman (NJ)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark.
ORCID: 0000-0003-4898-7839

Valerie Biousse (V)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark.
ORCID: 0000-0002-3594-850X

Dan Milea (D)

From the Singapore Eye Research Institute (C.V., R.P.N., Z.T., J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); Duke-NUS Medical School (R.P.N., J.L.L., S.S., S.T., T.Y.W., D.M.); Institute of High Performance Computing (X.X., Y.L.), Agency for Science, Technology and Research (A*STAR); Singapore National Eye Centre (J.L.L., S.S., S.T., D.S.W.T., T.Y.W., D.M.); University of Berkeley (L.M.), CA; Departments of Ophthalmology and Neurology (N.J.N., V.B.), Emory University School of Medicine, Atlanta, GA; and Copenhagen University Hospital (D.M.), Denmark. dan.milea@snec.com.sg.
ORCID: 0000-0002-6388-8639

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Classifications MeSH

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questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Accuracy of a Deep Learning System for...
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