MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration.
Aged
Animals
Binding Sites
Brain
/ metabolism
Case-Control Studies
Cell Differentiation
Disease Progression
Female
Humans
Internal Ribosome Entry Sites
/ genetics
Male
Mice
Mice, Transgenic
Middle Aged
Neurons
/ metabolism
Protein Biosynthesis
/ genetics
Proteostasis
/ genetics
RNA, Antisense
/ genetics
Ribosomes
/ metabolism
Tauopathies
/ genetics
tau Proteins
/ biosynthesis
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
15
04
2016
accepted:
15
04
2021
pubmed:
21
5
2021
medline:
27
7
2021
entrez:
20
5
2021
Statut:
ppublish
Résumé
The human genome expresses thousands of natural antisense transcripts (NAT) that can regulate epigenetic state, transcription, RNA stability or translation of their overlapping genes
Identifiants
pubmed: 34012113
doi: 10.1038/s41586-021-03556-6
pii: 10.1038/s41586-021-03556-6
pmc: PMC7610982
mid: EMS126982
doi:
Substances chimiques
Internal Ribosome Entry Sites
0
MAPT protein, human
0
RNA, Antisense
0
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-123Subventions
Organisme : Medical Research Council
ID : MR/K01417X/1
Pays : United Kingdom
Organisme : Parkinson's UK
ID : K-1212
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1001253
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L501542/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001002
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-0907
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202903/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001002
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J004758/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M02492X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001002
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001002
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S006591/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N008324/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N026004/1
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-1307
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701075
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0901254
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0501560
Pays : United Kingdom
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