Analysis of Pharmacokinetics in the Cochlea of the Inner Ear.
cochlea
ototoxic drug
pharmacokinetics
real-time measurement
sensorineural hearing loss
therapeutic reagent
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
25
11
2020
accepted:
16
04
2021
entrez:
20
5
2021
pubmed:
21
5
2021
medline:
21
5
2021
Statut:
epublish
Résumé
Hearing loss affects >5% of the global population and therefore, has a great social and clinical impact. Sensorineural hearing loss, which can be caused by different factors, such as acoustic trauma, aging, and administration of certain classes of drugs, stems primarily from a dysfunction of the cochlea in the inner ear. Few therapeutic strategies against sensorineural hearing loss are available. To develop effective treatments for this disease, it is crucial to precisely determine the behavior of ototoxic and therapeutic agents in the microenvironment of the cochlea in live animals. Since the 1980s, a number of studies have addressed this issue by different methodologies. However, there is much less information on pharmacokinetics in the cochlea than that in other organs; the delay in ontological pharmacology is likely due to technical difficulties with accessing the cochlea, a tiny organ that is encased with a bony wall and has a fine and complicated internal structure. In this review, we not only summarize the observations and insights obtained in classic and recent studies on pharmacokinetics in the cochlea but also describe relevant analytical techniques, with their strengths, limitations, and prospects.
Identifiants
pubmed: 34012393
doi: 10.3389/fphar.2021.633505
pii: 633505
pmc: PMC8128070
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
633505Informations de copyright
Copyright © 2021 Sawamura, Ogata, Asai, Razvina, Ota, Zhang, Madhurantakam, Akiyama, Ino, Kanzaki, Saiki, Matsumoto, Moriyama, Saijo, Horii, Einaga and Hibino.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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