Stereotactic radiotherapy for early stage non-small cell lung cancer: current standards and ongoing research.
Stereotactic body radiation therapy (SBRT)
early stage
lung cancer
non-small cell lung cancer (NSCLC)
stereotactic ablative radiotherapy (SABR)
Journal
Translational lung cancer research
ISSN: 2218-6751
Titre abrégé: Transl Lung Cancer Res
Pays: China
ID NLM: 101646875
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
entrez:
20
5
2021
pubmed:
21
5
2021
medline:
21
5
2021
Statut:
ppublish
Résumé
Stereotactic body radiation therapy (SBRT) allows for the non-invasive and precise delivery of ablative radiation dose. The use and availability of SBRT has increased rapidly over the past decades. SBRT has been proven to be a safe, effective and efficient treatment for early stage non-small cell lung cancer (NSCLC) and is presently considered the standard of care in the treatment of medically or functionally inoperable patients. Evidence from prospective randomized trials on the optimal treatment of patients deemed medically operable remains owing, as three trials comparing SBRT to surgery in this cohort were terminated prematurely due to poor accrual. Yet, SBRT in early stage NSCLC is associated with favorable toxicity profiles and excellent rates of local control, prompting discussion in regard of the treatment of medically operable patients, where the standard of care currently remains surgical resection. Although local control in early stage NSCLC after SBRT is high, distant failure remains an issue, prompting research interest to the combination of SBRT and systemic treatment. Evolving advances in SBRT technology further facilitate the safe treatment of patients with medically or anatomically challenging situations. In this review article, we discuss international guidelines and the current standard of care, ongoing clinical challenges and future directions from the clinical and technical point of view.
Identifiants
pubmed: 34012804
doi: 10.21037/tlcr-20-860
pii: tlcr-10-04-1930
pmc: PMC8107760
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1930-1949Informations de copyright
2021 Translational Lung Cancer Research. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tlcr-20-860). The series “Radiotherapy in thoracic malignancies” was commissioned by the editorial office without any funding or sponsorship. MG reports grants from Varian, AstraZeneca and Viewray, unrelated to this work. The authors have no other conflicts of interest to declare.
Références
J Thorac Oncol. 2011 Dec;6(12):2036-43
pubmed: 21892102
Int J Radiat Oncol Biol Phys. 2011 Feb 1;79(2):579-87
pubmed: 20656420
Med Phys. 2014 Nov;41(11):111719
pubmed: 25370633
Med Phys. 2014 Feb;41(2):020702
pubmed: 24506591
Strahlenther Onkol. 2009 Apr;185(4):231-4
pubmed: 19370425
Clin Lung Cancer. 2017 Jul;18(4):436-440.e1
pubmed: 28215851
Radiother Oncol. 2008 Sep;88(3):351-8
pubmed: 18722684
Anticancer Res. 2014 Sep;34(9):5099-104
pubmed: 25202098
Lung Cancer. 2013 Nov;82(2):260-5
pubmed: 24054547
Radiat Oncol. 2019 Jan 25;14(1):16
pubmed: 30683133
Pract Radiat Oncol. 2017 Sep - Oct;7(5):295-301
pubmed: 28596092
Thorac Surg Clin. 2015 May;25(2):185-97
pubmed: 25901562
Radiother Oncol. 2013 Mar;106(3):276-82
pubmed: 23462705
Phys Med Biol. 2011 Dec 7;56(23):7541-54
pubmed: 22079979
Am J Clin Oncol. 2014 Apr;37(2):148-53
pubmed: 23211223
Clin Lung Cancer. 2015 May;16(3):237-44
pubmed: 25604729
Lancet Oncol. 2015 Jun;16(6):630-7
pubmed: 25981812
Radiother Oncol. 2020 Jan;142:230-235
pubmed: 31481272
Radiother Oncol. 2018 Nov;129(2):218-226
pubmed: 30473058
Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):326-32
pubmed: 20117285
J Clin Oncol. 2009 Jul 10;27(20):3290-6
pubmed: 19414667
Med Phys. 2006 Oct;33(10):3874-900
pubmed: 17089851
Int J Radiat Oncol Biol Phys. 2010 Oct 1;78(2):467-71
pubmed: 20056349
J Vis Surg. 2017 Jun 22;3:86
pubmed: 29302412
Pract Radiat Oncol. 2019 Mar;9(2):e196-e202
pubmed: 30496842
J Clin Oncol. 2019 May 20;37(15):1316-1325
pubmed: 30943123
J Thorac Oncol. 2016 Jul;11(7):1081-9
pubmed: 27013408
Int J Radiat Oncol Biol Phys. 2015 Dec 1;93(5):989-96
pubmed: 26581137
Acta Oncol. 2015;54(8):1096-104
pubmed: 25813471
Ann Oncol. 2017 Jul 1;28(suppl_4):iv1-iv21
pubmed: 28881918
Radiother Oncol. 2007 Dec;85(3):429-34
pubmed: 18022720
Br J Cancer. 2004 Aug;91 Suppl 2:S3-10
pubmed: 15340372
Sci Transl Med. 2014 Jul 16;6(245):245ra93
pubmed: 25031268
J Thorac Oncol. 2015 May;10(5):832-837
pubmed: 25634007
J Clin Oncol. 2006 Oct 20;24(30):4833-9
pubmed: 17050868
Int J Radiat Oncol Biol Phys. 2013 Aug 1;86(5):964-8
pubmed: 23845845
Int J Radiat Oncol Biol Phys. 2015 Jan 1;91(1):124-32
pubmed: 25442337
Clin Lung Cancer. 2018 Jul;19(4):e529-e532
pubmed: 29759332
J Thorac Oncol. 2018 Nov;13(11):1727-1732
pubmed: 30056162
Med Phys. 2013 Sep;40(9):091713
pubmed: 24007146
Cancer Res Treat. 2015 Oct;47(4):676-86
pubmed: 25687856
J Thorac Oncol. 2013 Feb;8(2):192-201
pubmed: 23287852
Radiother Oncol. 2014 Mar;110(3):505-10
pubmed: 24444530
Jpn J Thorac Cardiovasc Surg. 2002 Oct;50(10):413-7
pubmed: 12428380
Int J Radiat Oncol Biol Phys. 2016 Sep 1;96(1):134-41
pubmed: 27325481
Int J Radiat Oncol Biol Phys. 2018 Nov 1;102(3):619-626
pubmed: 30017793
PLoS One. 2015 Oct 13;10(10):e0140437
pubmed: 26460792
Med Phys. 2016 Oct;43(10):5695
pubmed: 27782689
Pract Radiat Oncol. 2019 Jan;9(1):e55-e61
pubmed: 30261329
Int J Radiat Oncol Biol Phys. 2006 Sep 1;66(1):117-25
pubmed: 16765528
Lung Cancer. 2018 Aug;122:107-112
pubmed: 30032817
Int J Clin Oncol. 2015 Feb;20(1):45-52
pubmed: 24610080
Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):146-154
pubmed: 27843029
Acta Oncol. 2006;45(7):796-801
pubmed: 16982542
Radiother Oncol. 2016 Oct;121(1):1-8
pubmed: 27600155
J Thorac Oncol. 2012 Sep;7(9):1462-5
pubmed: 22895143
Lung Cancer. 2015 Jul;89(1):50-6
pubmed: 25997421
Radiat Oncol. 2017 Jan 27;12(1):30
pubmed: 28129789
Ther Adv Respir Dis. 2014 Feb;8(1):3-12
pubmed: 24334338
N Engl J Med. 2020 Feb 6;382(6):503-513
pubmed: 31995683
J Thorac Cardiovasc Surg. 2012 Sep;144(3):S35-8
pubmed: 22795435
Int J Radiat Oncol Biol Phys. 2006 May 1;65(1):107-11
pubmed: 16458447
Transl Lung Cancer Res. 2019 Sep;8(Suppl 2):S202-S212
pubmed: 31673525
Radiat Oncol. 2016 Oct 3;11(1):131
pubmed: 27716240
Clin Lung Cancer. 2018 Mar;19(2):e219-e226
pubmed: 29066051
Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):195-203
pubmed: 27816362
N Engl J Med. 2015 Oct 22;373(17):1627-39
pubmed: 26412456
Radiat Oncol. 2018 Jul 28;13(1):136
pubmed: 30055636
Cancer. 2010 May 15;116(10):2476-85
pubmed: 20225229
J Thorac Oncol. 2019 Apr;14(4):583-595
pubmed: 30721798
PLoS One. 2017 Apr 11;12(4):e0175589
pubmed: 28399182
Acta Oncol. 1994;33(6):677-83
pubmed: 7946448
Lung Cancer. 2012 Jul;77(1):77-82
pubmed: 22300750
Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):786-93
pubmed: 17379439
Proc Natl Acad Sci U S A. 2019 May 28;116(22):10943-10951
pubmed: 31097580
J Thorac Oncol. 2015 Apr;10(4):577-85
pubmed: 25514807
JAMA. 2010 Mar 17;303(11):1070-6
pubmed: 20233825
Lancet Oncol. 2019 Apr;20(4):494-503
pubmed: 30770291
J Thorac Oncol. 2007 Oct;2(10):916-26
pubmed: 17909354
Lung Cancer Manag. 2018 Apr 17;7(1):LMT01
pubmed: 30643580
Radiother Oncol. 2017 Jul;124(1):11-17
pubmed: 28687397
Radiat Oncol. 2020 Feb 27;15(1):61
pubmed: 32106868
Phys Med Biol. 2020 Jan 17;65(2):025008
pubmed: 31783395
Strahlenther Onkol. 2014 Jan;190(1):26-33
pubmed: 24052011
Cancer. 1998 Mar 15;82(6):1062-70
pubmed: 9506350
Med Phys. 2009 Sep;36(9):4197-212
pubmed: 19810494
J Thorac Oncol. 2015 Jan;10(1):116-25
pubmed: 25376512
Int J Radiat Oncol Biol Phys. 2012 May 1;83(1):348-53
pubmed: 22104360
J Thorac Oncol. 2013 Aug;8(8):1050-8
pubmed: 23817193
Ann Oncol. 2014 Aug;25(8):1462-74
pubmed: 24562446
Radiother Oncol. 2014 Aug;112(2):256-61
pubmed: 25108807
J Radiat Res. 2012;53(1):110-6
pubmed: 22302051
J Med Case Rep. 2017 Dec 10;11(1):343
pubmed: 29223168
Int J Radiat Oncol Biol Phys. 2014 Dec 1;90(5):1168-76
pubmed: 25303891
Med Phys. 2014 Nov;41(11):111712
pubmed: 25370626
Int J Radiat Oncol Biol Phys. 2019 Jan 1;103(1):132-141
pubmed: 30176275
Radiother Oncol. 2017 Sep;124(3):365-369
pubmed: 28545957
Phys Med Biol. 2004 Feb 7;49(3):425-40
pubmed: 15012011
J Appl Clin Med Phys. 2017 Sep;18(5):10-21
pubmed: 28786239
Med Phys. 2010 Aug;37(8):4078-101
pubmed: 20879569
Radiother Oncol. 2019 Oct;139:40-45
pubmed: 30755324
Radiother Oncol. 2017 Jul;124(1):18-24
pubmed: 28655454
Clin Lung Cancer. 2018 Mar;19(2):e269-e276
pubmed: 29208356
Radiother Oncol. 2013 Oct;109(1):51-7
pubmed: 23953413
Lung Cancer. 2019 Apr;130:162-168
pubmed: 30885339
Int J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):1121-8
pubmed: 26907916
J Radiat Oncol. 2015;4(1):65-70
pubmed: 25774244
Med Phys. 2012 Apr;39(4):1728-47
pubmed: 22482598
JAMA Oncol. 2018 Sep 1;4(9):1263-1266
pubmed: 29852037
JNCI Cancer Spectr. 2017 Oct 12;1(1):pkx003
pubmed: 31360829
Acta Oncol. 2019 Oct;58(10):1463-1469
pubmed: 31241377
Int J Radiat Oncol Biol Phys. 2011 Mar 15;79(4):1225-31
pubmed: 20732759
Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):685-92
pubmed: 18164849
Int J Radiat Oncol Biol Phys. 2018 Jul 1;101(3):558-563
pubmed: 29680255
J Thorac Cardiovasc Surg. 2017 Aug;154(2):689-699
pubmed: 28495066
Chest. 2005 Oct;128(4):2490-6
pubmed: 16236914
Radiother Oncol. 2017 Jun;123(3):346-354
pubmed: 28545956
Int J Radiat Oncol Biol Phys. 2011 Jul 15;80(4):1015-22
pubmed: 20615629
Transl Lung Cancer Res. 2018 Apr;7(2):199-204
pubmed: 29876319
Clin Cancer Res. 2019 Jan 1;25(1):35-42
pubmed: 29875213
Thorax. 2008 Sep;63 Suppl 5:v1-58
pubmed: 18757459
Radiother Oncol. 2011 Nov;101(2):260-6
pubmed: 22056534
Lung Cancer. 2010 Apr;68(1):72-7
pubmed: 19556022
Radiother Oncol. 2016 Oct;121(1):19-25
pubmed: 27650013
Radiother Oncol. 2008 Sep;88(3):368-75
pubmed: 18405986
Int J Radiat Oncol Biol Phys. 2014 Nov 1;90(3):603-11
pubmed: 25052562
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Chest. 2012 Oct;142(4):1005-1010
pubmed: 22797563
Radiat Oncol. 2010 May 09;5:32
pubmed: 20459699
Pract Radiat Oncol. 2016 Sep-Oct;6(5):367-374
pubmed: 27068780
Med Phys. 2009 Aug;36(8):3477-86
pubmed: 19746781
Pract Radiat Oncol. 2016 Mar-Apr;6(2):e27-33
pubmed: 26577006
Int J Radiat Oncol Biol Phys. 2009 Nov 1;75(3):950-8
pubmed: 19801106
J Thorac Oncol. 2007 Jul;2(7 Suppl 3):S94-100
pubmed: 17603311
Int J Radiat Oncol Biol Phys. 2018 May 1;101(1):186-194
pubmed: 29619964
Br J Radiol. 2015 Jul;88(1051):20150036
pubmed: 25873481
Radiother Oncol. 2011 Nov;101(2):250-4
pubmed: 22056535
Lancet Oncol. 2012 Aug;13(8):802-9
pubmed: 22727222
Int J Radiat Oncol Biol Phys. 2014 Oct 1;90(2):402-6
pubmed: 25017480
Med Phys. 2010 Feb;37(2):753-61
pubmed: 20229885
Thorac Cancer. 2018 Jun;9(6):699-706
pubmed: 29697204
J Thorac Cardiovasc Surg. 2019 Jan;157(1):362-373.e8
pubmed: 30482524
Radiother Oncol. 2010 Dec;97(3):425-30
pubmed: 20934768
J Thorac Oncol. 2015 Jul;10(7):990-1003
pubmed: 26134221
Int J Radiat Oncol Biol Phys. 2007 Mar 1;67(3):750-8
pubmed: 17293232
Radiother Oncol. 2019 Oct;139:28-33
pubmed: 31178058
Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1087-96
pubmed: 16682145
Radiother Oncol. 2013 Jun;107(3):423-7
pubmed: 23647748