Clinicopathologic and molecular characterization of melanomas mutated for CTNNB1 and MAPK.
BRAF mutation
CTNNB1 mutation
Cutaneous melanoma
Deep penetrating nevus
NRAS mutation
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
28
10
2020
accepted:
09
05
2021
revised:
04
05
2021
pubmed:
21
5
2021
medline:
9
4
2022
entrez:
20
5
2021
Statut:
ppublish
Résumé
Wnt/β-catenin signaling plays crucial roles in melanocyte biology and may be implicated in melanoma progression. In this study, we retrospectively examined a real-life cohort of melanomas mutated for β-catenin (CTNNB1), in association or not with a MAPK mutation (of BRAF or NRAS), and analyzed their clinical, histopathological, and molecular characteristics. Our results indicate that, regardless of the presence of a concurrent MAPK mutation, CTNNB1
Identifiants
pubmed: 34013383
doi: 10.1007/s00428-021-03119-0
pii: 10.1007/s00428-021-03119-0
doi:
Substances chimiques
CTNNB1 protein, human
0
beta Catenin
0
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
475-480Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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