Decreased exercise capacity, strength, physical activity level and quality of life in adult patients with familial Mediterranean fever
Exercise capacity
familial Mediterranean fever
muscle strength
physical activity
quality of life
Journal
Turkish journal of medical sciences
ISSN: 1303-6165
Titre abrégé: Turk J Med Sci
Pays: Turkey
ID NLM: 9441758
Informations de publication
Date de publication:
30 08 2021
30 08 2021
Historique:
received:
08
11
2020
accepted:
16
05
2021
entrez:
20
5
2021
pubmed:
21
5
2021
medline:
1
1
2022
Statut:
epublish
Résumé
Familial Mediterranean fever (FMF) is a systemic autoinflammatory disease that causes recurrent attacks of fever, polyserositis, arthritis or skin eruptions, resulting in pain in the abdomen, muscles, joints and chest. All of these might lead to a reduction in exercise capacity, muscle strength, physical activity level (PAL) and quality of life (QoL). Therefore, assesment of these parameters are important. The aim of this study was to assess exercise capacity, muscle strength, PAL, and QoL in patients with FMF as compared to controls. A total of 40 subjects with FMF and 36 healthy control subjects participated in the study. The 6-minute walk test (6MWT) was used to assess exercise capacity. Muscle strength measurements for shoulder flexors, extensors and abductors, hip flexors, extensors and abductors, knee flexors and extensors, and ankle dorsiflexors were evaluated by hand-held dynamometer. PAL was assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF). QoL was investigated by Nottingham Health Profile (NHP). Significant differences were found between patients and healthy subjects for 6MWT (p = 0.003), muscle strength of ankle dorsiflexors (p = 0.001), hip flexors (p = 0.047), extensors (p = 0.003) and abductors (p = 0.004), total scores of IPAQ-SF (p = 0.004), and pain (p < 0.001), physical mobility (p < 0.001) and energy level (p = 0.026) subscales of NHP. However, there were no significant differences between groups for the shoulder flexion (p = 0.089), extension (p = 0.440) and abduction (p = 0.232), hand grip strength (p = 0.160) , and knee flexion (p = 0.744) and extension (p = 0.155) muscle strength and emotional reaction (p = 0.088), sleep (p = 0.070) and social isolation (p = 0.086) subsets of NHP. Subjects with FMF demonstrated lower exercise capacity, muscle strength, PAL and QoL than healthy peers. Therefore, it is important to evaluate and improve these parameters in patients with FMF.
Sections du résumé
Background
Familial Mediterranean fever (FMF) is a systemic autoinflammatory disease that causes recurrent attacks of fever, polyserositis, arthritis or skin eruptions, resulting in pain in the abdomen, muscles, joints and chest. All of these might lead to a reduction in exercise capacity, muscle strength, physical activity level (PAL) and quality of life (QoL). Therefore, assesment of these parameters are important. The aim of this study was to assess exercise capacity, muscle strength, PAL, and QoL in patients with FMF as compared to controls.
Materials and methods
A total of 40 subjects with FMF and 36 healthy control subjects participated in the study. The 6-minute walk test (6MWT) was used to assess exercise capacity. Muscle strength measurements for shoulder flexors, extensors and abductors, hip flexors, extensors and abductors, knee flexors and extensors, and ankle dorsiflexors were evaluated by hand-held dynamometer. PAL was assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF). QoL was investigated by Nottingham Health Profile (NHP).
Results
Significant differences were found between patients and healthy subjects for 6MWT (p = 0.003), muscle strength of ankle dorsiflexors (p = 0.001), hip flexors (p = 0.047), extensors (p = 0.003) and abductors (p = 0.004), total scores of IPAQ-SF (p = 0.004), and pain (p < 0.001), physical mobility (p < 0.001) and energy level (p = 0.026) subscales of NHP. However, there were no significant differences between groups for the shoulder flexion (p = 0.089), extension (p = 0.440) and abduction (p = 0.232), hand grip strength (p = 0.160) , and knee flexion (p = 0.744) and extension (p = 0.155) muscle strength and emotional reaction (p = 0.088), sleep (p = 0.070) and social isolation (p = 0.086) subsets of NHP.
Conclusion
Subjects with FMF demonstrated lower exercise capacity, muscle strength, PAL and QoL than healthy peers. Therefore, it is important to evaluate and improve these parameters in patients with FMF.
Identifiants
pubmed: 34013704
doi: 10.3906/sag-2011-98
pmc: PMC8569751
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1712-1718Informations de copyright
This work is licensed under a Creative Commons Attribution 4.0 International License.
Références
Eur J Clin Nutr. 2017 Dec;71(12):1399-1404
pubmed: 28656974
Dev Neurorehabil. 2011;14(1):41-53
pubmed: 21034288
Arch Phys Med Rehabil. 1997 Jan;78(1):26-32
pubmed: 9014953
Am J Respir Crit Care Med. 2002 Jul 1;166(1):111-7
pubmed: 12091180
Rheumatol Int. 2006 Apr;26(6):489-96
pubmed: 16283319
Percept Mot Skills. 2010 Aug;111(1):278-84
pubmed: 21058606
Arthritis Rheum. 2008 Jan 15;59(1):42-50
pubmed: 18163412
Clin Exp Rheumatol. 1997 Jul-Aug;15(4):355-60
pubmed: 9272294
Arthritis Rheum. 2005 Jun 15;53(3):351-6
pubmed: 15934128
Soc Sci Med A. 1981 May;15(3 Pt 1):221-9
pubmed: 6973203
J Hand Surg Am. 1984 Mar;9(2):222-6
pubmed: 6715829
Rev Bras Reumatol. 2011 Sep-Oct;51(5):490-6
pubmed: 21953000
J Am Geriatr Soc. 2010 Nov;58(11):2055-62
pubmed: 21054284
Arthritis Rheum. 2001 Jun;44(6):1416-9
pubmed: 11407703
N Engl J Med. 1987 Jun 18;316(25):1562-8
pubmed: 3035372
Acta Medica (Hradec Kralove). 2014;57(3):97-104
pubmed: 25649364
Arthritis Care Res (Hoboken). 2012 Apr;64(4):488-93
pubmed: 22278986
Autoimmun Rev. 2010 Jun;9(8):569-73
pubmed: 20388559
Phys Ther. 1996 Mar;76(3):248-59
pubmed: 8602410
Pediatr Phys Ther. 2014 Fall;26(3):353
pubmed: 24979094
J Rheumatol. 1994 Sep;21(9):1708-9
pubmed: 7799354
Eur Rev Med Pharmacol Sci. 2013 Apr;17(7):958-63
pubmed: 23640444
Eur J Pediatr. 1989 Jun;148(7):636-41
pubmed: 2663516
Rheumatol Int. 2011 May;31(5):623-8
pubmed: 20049448
Lancet. 1998 Feb 28;351(9103):659-64
pubmed: 9500348
Health Qual Life Outcomes. 2013 May 04;11:75
pubmed: 23642162
Pediatr Clin North Am. 2005 Apr;52(2):577-609, vii
pubmed: 15820380
Clin Rheumatol. 2019 Jul;38(7):1941-1946
pubmed: 30826946
Pediatr Phys Ther. 2014 Fall;26(3):347-52
pubmed: 24979093
Osteoporos Int. 2000;11(11):944-52
pubmed: 11193247
Ann Rheum Dis. 2016 Apr;75(4):644-51
pubmed: 26802180