Hijacking of the host cell Golgi by Plasmodium berghei liver stage parasites.
Plasmodium liver-stages
CLASP
Golgi-associated vesicular traffic
Host cell Golgi
Host-parasite interaction
Organelle hijacking
Journal
Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457
Informations de publication
Date de publication:
15 05 2021
15 05 2021
Historique:
received:
27
07
2020
accepted:
12
04
2021
entrez:
20
5
2021
pubmed:
21
5
2021
medline:
13
7
2021
Statut:
ppublish
Résumé
The intracellular lifestyle represents a challenge for the rapidly proliferating liver stage Plasmodium parasite. In order to scavenge host resources, Plasmodium has evolved the ability to target and manipulate host cell organelles. Using dynamic fluorescence-based imaging, we here show an interplay between the pre-erythrocytic stages of Plasmodium berghei and the host cell Golgi during liver stage development. Liver stage schizonts fragment the host cell Golgi into miniaturized stacks, which increases surface interactions with the parasitophorous vacuolar membrane of the parasite. Expression of specific dominant-negative Arf1 and Rab GTPases, which interfere with the host cell Golgi-linked vesicular machinery, results in developmental delay and diminished survival of liver stage parasites. Moreover, functional Rab11a is critical for the ability of the parasites to induce Golgi fragmentation. Altogether, we demonstrate that the structural integrity of the host cell Golgi and Golgi-associated vesicular traffic is important for optimal pre-erythrocytic development of P. berghei. The parasite hijacks the Golgi structure of the hepatocyte to optimize its own intracellular development. This article has an associated First Person interview with the first author of the paper.
Identifiants
pubmed: 34013963
pii: 268311
doi: 10.1242/jcs.252213
pmc: PMC8186485
pii:
doi:
Substances chimiques
Protozoan Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing or financial interests.
Références
J Biol Chem. 2002 Mar 8;277(10):7962-9
pubmed: 11773070
Clin Microbiol Rev. 2009 Apr;22(2):240-73, Table of Contents
pubmed: 19366914
Biochim Biophys Acta. 2005 Jul 10;1744(3):364-73
pubmed: 15979507
Int J Med Microbiol. 2012 Oct;302(4-5):179-86
pubmed: 22898489
Small GTPases. 2018 Mar 4;9(1-2):182-191
pubmed: 28632996
Biol Open. 2019 Mar 18;8(3):
pubmed: 30814066
Nat Rev Microbiol. 2016 Jul;14(7):407-420
pubmed: 27265768
Cell Host Microbe. 2014 Dec 10;16(6):778-86
pubmed: 25498345
PLoS Pathog. 2009 Oct;5(10):e1000615
pubmed: 19816566
Cell Rep. 2014 Mar 13;6(5):878-91
pubmed: 24582959
Nat Cell Biol. 2009 Sep;11(9):1069-80
pubmed: 19701196
Small GTPases. 2019 Nov;10(6):411-418
pubmed: 28524754
PLoS Pathog. 2011 Sep;7(9):e1002224
pubmed: 21909271
Biochem Soc Trans. 2005 Aug;33(Pt 4):639-42
pubmed: 16042562
Mol Microbiol. 2016 Dec;102(5):775-791
pubmed: 27566438
Cell Microbiol. 2016 Mar;18(3):437-50
pubmed: 26399761
Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1138-E1147
pubmed: 28137845
Mol Biol Cell. 2013 Jun;24(12):1974-95
pubmed: 23615442
Biochem J. 2011 Jan 1;433(1):1-9
pubmed: 21158737
Nature. 2013 Apr 4;496(7443):106-9
pubmed: 23535599
Cell Microbiol. 2017 Oct;19(10):
pubmed: 28573684
Sci Rep. 2019 May 28;9(1):7967
pubmed: 31138850
Small GTPases. 2011 Jul;2(4):217-221
pubmed: 22145094
Annu Rev Cell Dev Biol. 2007;23:579-611
pubmed: 17506703
Nat Rev Immunol. 2006 Feb;6(2):136-47
pubmed: 16491138
Cell Microbiol. 2018 Jul;20(7):e12857
pubmed: 29748997
Microbiol Mol Biol Rev. 2007 Dec;71(4):636-52
pubmed: 18063721
Small GTPases. 2018 Mar 4;9(1-2):66-75
pubmed: 29099310
Science. 1996 Aug 9;273(5276):797-801
pubmed: 8670420
Cell Chem Biol. 2019 Sep 19;26(9):1253-1262.e5
pubmed: 31257182
Curr Opin Struct Biol. 2005 Dec;15(6):681-9
pubmed: 16289847
J Cell Biol. 2017 Dec 4;216(12):4235-4254
pubmed: 29070609
Nat Rev Immunol. 2003 Jul;3(7):557-68
pubmed: 12876558
Cell Cycle. 2003 Nov-Dec;2(6):511-4
pubmed: 14504462
Cell Host Microbe. 2012 Nov 15;12(5):717-29
pubmed: 23159060
J Biol Chem. 2005 Jan 14;280(2):1392-400
pubmed: 15520000
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3022-7
pubmed: 15699336
Biochemistry (Mosc). 2019 Dec;84(12):1490-1501
pubmed: 31870253
Nat Rev Mol Cell Biol. 2008 Apr;9(4):273-84
pubmed: 18354421
Nat Microbiol. 2017 Dec;2(12):1600-1607
pubmed: 28947801
PLoS Pathog. 2015 Mar 18;11(3):e1004760
pubmed: 25786000
Cell Microbiol. 2004 Nov;6(11):1027-40
pubmed: 15469432
Autophagy. 2013 Apr;9(4):568-80
pubmed: 23388496
Biochim Biophys Acta Mol Cell Res. 2018 Jul 17;1865(10):1397-1409
pubmed: 30021127
Traffic. 2018 May;19(5):336-353
pubmed: 29437275
Cell Microbiol. 2014 Mar;16(3):324-33
pubmed: 24330249
Biochem J. 2006 Feb 15;394(Pt 1):197-205
pubmed: 16246004
Autophagy. 2015;11(9):1561-79
pubmed: 26208778
Cell. 2004 Jan 23;116(2):153-66
pubmed: 14744428
Small GTPases. 2018 Mar 4;9(1-2):192-201
pubmed: 28696820
Histochemistry. 1984;81(5):417-25
pubmed: 6083994
PLoS Pathog. 2016 Nov 16;12(11):e1005917
pubmed: 27851824
Nat Microbiol. 2018 Jan;3(1):17-25
pubmed: 29109477
Eur J Cell Biol. 1993 Apr;60(2):217-27
pubmed: 7687214
Traffic. 2012 Dec;13(12):1565-88
pubmed: 22901006
FEMS Microbiol Rev. 2018 May 1;42(3):324-334
pubmed: 29529207
Trends Cell Biol. 2014 Jul;24(7):407-15
pubmed: 24675420
Int J Biochem Cell Biol. 2012 Feb;44(2):266-74
pubmed: 22108200
FEBS Lett. 2009 Sep 3;583(17):2701-9
pubmed: 19631211
Sci Rep. 2017 May 19;7(1):2191
pubmed: 28526861
Science. 2002 Jan 25;295(5555):679-82
pubmed: 11809974
Nat Cell Biol. 2002 Oct;4(10):E236-42
pubmed: 12360306
Malar J. 2016 Apr 21;15:232
pubmed: 27102897
Cell. 2012 Aug 31;150(5):1029-41
pubmed: 22939626
Cell. 2003 Jun 27;113(7):891-904
pubmed: 12837247
Traffic. 2014 Apr;15(4):362-82
pubmed: 24423236
Mol Biol Cell. 2017 Mar 15;28(6):712-715
pubmed: 28292916
Nature. 2009 Feb 5;457(7230):731-5
pubmed: 19060882
Nature. 2005 Jan 13;433(7022):164-7
pubmed: 15580261
Biochim Biophys Acta. 2005 Jul 10;1744(3):383-95
pubmed: 15979508
Nat Rev Mol Cell Biol. 2013 Jun;14(6):382-92
pubmed: 23698585
Annu Rev Cell Dev Biol. 2017 Oct 6;33:51-75
pubmed: 28645217
Front Cell Dev Biol. 2018 Jan 24;6:1
pubmed: 29417046
Nat Rev Microbiol. 2006 Nov;4(11):849-56
pubmed: 17041632
Adv Virus Res. 2019;104:97-122
pubmed: 31439154
Nat Rev Mol Cell Biol. 2006 May;7(5):347-58
pubmed: 16633337
Mol Biol Cell. 2017 Mar 15;28(6):726-735
pubmed: 28122820
Cell. 2006 Apr 21;125(2):261-74
pubmed: 16630815
J Biol Chem. 1994 Jan 14;269(2):1437-48
pubmed: 8288610
Int J Parasitol. 2007 Oct;37(12):1329-41
pubmed: 17537443
Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3519-28
pubmed: 27185909
EMBO Rep. 2015 Aug;16(8):955-64
pubmed: 26113366
Cell Struct Funct. 1996 Feb;21(1):47-52
pubmed: 8726473