An examination of school reopening strategies during the SARS-CoV-2 pandemic.


Journal

PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081

Informations de publication

Date de publication:
2021
Historique:
received: 30 11 2020
accepted: 22 04 2021
entrez: 20 5 2021
pubmed: 21 5 2021
medline: 4 6 2021
Statut: epublish

Résumé

The SARS-CoV-2 pandemic led to closure of nearly all K-12 schools in the United States of America in March 2020. Although reopening K-12 schools for in-person schooling is desirable for many reasons, officials understand that risk reduction strategies and detection of cases are imperative in creating a safe return to school. Furthermore, consequences of reclosing recently opened schools are substantial and impact teachers, parents, and ultimately educational experiences in children. To address competing interests in meeting educational needs with public safety, we compare the impact of physical separation through school cohorts on SARS-CoV-2 infections against policies acting at the level of individual contacts within classrooms. Using an age-stratified Susceptible-Exposed-Infected-Removed model, we explore influences of reduced class density, transmission mitigation, and viral detection on cumulative prevalence. We consider several scenarios over a 6-month period including (1) multiple rotating cohorts in which students cycle through in-person instruction on a weekly basis, (2) parallel cohorts with in-person and remote learning tracks, (3) the impact of a hypothetical testing program with ideal and imperfect detection, and (4) varying levels of aggregate transmission reduction. Our mathematical model predicts that reducing the number of contacts through cohorts produces a larger effect than diminishing transmission rates per contact. Specifically, the latter approach requires dramatic reduction in transmission rates in order to achieve a comparable effect in minimizing infections over time. Further, our model indicates that surveillance programs using less sensitive tests may be adequate in monitoring infections within a school community by both keeping infections low and allowing for a longer period of instruction. Lastly, we underscore the importance of factoring infection prevalence in deciding when a local outbreak of infection is serious enough to require reverting to remote learning.

Identifiants

pubmed: 34014947
doi: 10.1371/journal.pone.0251242
pii: PONE-D-20-37682
pmc: PMC8136712
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0251242

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM053275
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG006139
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM141798
Pays : United States

Commentaires et corrections

Type : UpdateOf

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

Références

MMWR Morb Mortal Wkly Rep. 2021 Feb 12;70(6):223
pubmed: 33571177
Acta Paediatr. 2020 Jun;109(6):1088-1095
pubmed: 32202343
Clin Infect Dis. 2020 Dec 06;:
pubmed: 33283240
Nat Microbiol. 2020 Dec;5(12):1598-1607
pubmed: 33106674
Science. 2020 Jun 26;368(6498):1481-1486
pubmed: 32350060
J Infect. 2020 Jun;80(6):e32-e33
pubmed: 32209383
JAMA Pediatr. 2021 Feb 1;175(2):143-156
pubmed: 32975552
J Med Virol. 2020 Sep;92(9):1380-1382
pubmed: 32281679
Nat Med. 2020 Aug;26(8):1205-1211
pubmed: 32546824
Sci Adv. 2021 Jan 1;7(1):
pubmed: 33219112
JAMA. 2020 Sep 1;324(9):859-870
pubmed: 32745200
J Glob Health. 2020 Jun;10(1):010376
pubmed: 32612815
Science. 2020 May 1;368(6490):489-493
pubmed: 32179701
BMC Public Health. 2020 Nov 16;20(1):1713
pubmed: 33198707
Ann Intern Med. 2020 May 5;172(9):577-582
pubmed: 32150748
Emerg Infect Dis. 2020 Jun;26(6):1341-1343
pubmed: 32191173
Lancet Infect Dis. 2020 Jul;20(7):793-802
pubmed: 32247326
JAMA Netw Open. 2020 Jul 1;3(7):e2016818
pubmed: 32735339
Nature. 2021 Mar;591(7851):639-644
pubmed: 33461210
Elife. 2020 Apr 02;9:
pubmed: 32228860
Science. 2021 Feb 5;371(6529):
pubmed: 33408181
Lancet. 2020 Jun 6;395(10239):1771-1778
pubmed: 32410760
Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32293-32301
pubmed: 33273115
MMWR Morb Mortal Wkly Rep. 2020 Aug 07;69(31):1023-1025
pubmed: 32759921
Emerg Infect Dis. 2020 Oct;26(10):2465-2468
pubmed: 32673193
Pediatr Infect Dis J. 2020 May;39(5):355-368
pubmed: 32310621
MMWR Morb Mortal Wkly Rep. 2020 Sep 18;69(37):1319-1323
pubmed: 32941418
Cell. 2021 Mar 4;184(5):1201-1213.e14
pubmed: 33571429
Clin Infect Dis. 2021 Mar 15;72(6):1055-1058
pubmed: 32584975
Nat Med. 2020 May;26(5):672-675
pubmed: 32296168
N Engl J Med. 2020 Jul 23;383(4):347-358
pubmed: 32598830

Auteurs

Alfonso Landeros (A)

Department of Computational Medicine, UCLA, Los Angeles, CA, United States of America.

Xiang Ji (X)

Department of Mathematics, Tulane University, New Orleans, LA, United States of America.

Kenneth Lange (K)

Department of Computational Medicine, UCLA, Los Angeles, CA, United States of America.
Department of Human Genetics, UCLA, Los Angeles, CA, United States of America.
Department of Statistics, UCLA, Los Angeles, CA, United States of America.

Timothy C Stutz (TC)

Department of Computational Medicine, UCLA, Los Angeles, CA, United States of America.

Jason Xu (J)

Department of Statistical Science, Duke University, Durham, NC, United States of America.

Mary E Sehl (ME)

Department of Computational Medicine, UCLA, Los Angeles, CA, United States of America.
Division of Hematology-Oncology, Department of Medicine, UCLA, Los Angeles, CA, United States of America.

Janet S Sinsheimer (JS)

Department of Computational Medicine, UCLA, Los Angeles, CA, United States of America.
Department of Human Genetics, UCLA, Los Angeles, CA, United States of America.
Department of Biostatistics, UCLA, Los Angeles, CA, United States of America.

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