Retinal vasodilatory responses are inversely associated with plasminogen activator inhibitor-1: The African-PREDICT study.
Adult
Age Factors
Biomarkers
/ blood
Cardiovascular Diseases
/ blood
Cross-Sectional Studies
Female
Healthy Volunteers
Humans
Light
Male
Photic Stimulation
Plasminogen Activator Inhibitor 1
/ blood
Predictive Value of Tests
Retinal Vessels
/ physiology
Risk Factors
South Africa
Vasodilation
Venules
/ physiology
Young Adult
Dynamic vessel analysis
Endothelial dysfunction
Inflammation
Plasminogen activator inhibitor-1
Retinal vascular function
Journal
Microvascular research
ISSN: 1095-9319
Titre abrégé: Microvasc Res
Pays: United States
ID NLM: 0165035
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
08
02
2021
revised:
28
04
2021
accepted:
13
05
2021
pubmed:
21
5
2021
medline:
8
1
2022
entrez:
20
5
2021
Statut:
ppublish
Résumé
Plasminogen activator inhibitor-1 (PAI-1), traditionally associated with fibrinolysis, is increasingly implicated in impaired vascular function. However, studies on its association with microvascular function are limited to the cutaneous and coronary microvascular beds in older and diseased individuals. To better understand its potential involvement in the early stages of disease development, we investigated the associations of retinal vasodilatory responses to flicker light with PAI-1 activity (PAI-1 We included healthy Black and White women and men (n = 518; aged 20-30 years), and measured plasma PAI-1 In multivariate regression analyses, maximal retinal venular dilation associated independently and inversely with PAI-1 Our data suggest that in young individuals, PAI-1 may already be associated with subclinical microvascular dysfunction.
Identifiants
pubmed: 34015274
pii: S0026-2862(21)00050-9
doi: 10.1016/j.mvr.2021.104180
pii:
doi:
Substances chimiques
Biomarkers
0
Plasminogen Activator Inhibitor 1
0
SERPINE1 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104180Subventions
Organisme : Medical Research Council
ID : MC_PC_16095
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.