Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial.
Biomarker endpoint
Clinical trial
Ibudilast
MIF
Neurofilament
PBR28
Phase 1b
TNF-alpha
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
12
2020
revised:
13
03
2021
accepted:
10
04
2021
pubmed:
22
5
2021
medline:
31
7
2021
entrez:
21
5
2021
Statut:
ppublish
Résumé
Ibudilast (MN-166) is an inhibitor of macrophage migration inhibitory factor (MIF) and phosphodiesterases 3,4,10 and 11 (Gibson et al., 2006; Cho et al., 2010). Ibudilast attenuates CNS microglial activation and secretion of pro-inflammatory cytokines (Fujimoto et al., 1999; Cho et al., 2010). In vitro evidence suggests that ibudilast is neuroprotective by suppressing neuronal cell death induced by microglial activation. People with ALS have increased microglial activation measured by [
Identifiants
pubmed: 34016561
pii: S2213-1582(21)00116-9
doi: 10.1016/j.nicl.2021.102672
pmc: PMC8102622
pii:
doi:
Substances chimiques
Biomarkers
0
Pyridines
0
ibudilast
M0TTH61XC5
Banques de données
ClinicalTrials.gov
['NCT02714036']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102672Subventions
Organisme : NIH HHS
ID : S10 OD023517
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
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