Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants.
Angiotensin-Converting Enzyme 2
/ metabolism
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
Antigenic Variation
Antigens, Viral
/ chemistry
Binding Sites
Binding Sites, Antibody
COVID-19
/ immunology
Epitopes
Humans
Immune Evasion
Mutation
Protein Binding
Protein Domains
Receptors, Coronavirus
/ metabolism
SARS-CoV-2
/ chemistry
Spike Glycoprotein, Coronavirus
/ chemistry
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
13 08 2021
13 08 2021
Historique:
received:
17
02
2021
accepted:
12
05
2021
pubmed:
22
5
2021
medline:
21
8
2021
entrez:
21
5
2021
Statut:
ppublish
Résumé
Neutralizing antibodies (nAbs) elicited against the receptor binding site (RBS) of the spike protein of wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are generally less effective against recent variants of concern. RBS residues Glu
Identifiants
pubmed: 34016740
pii: science.abh1139
doi: 10.1126/science.abh1139
pmc: PMC8284396
mid: NIHMS1712455
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Antigens, Viral
0
Epitopes
0
Receptors, Coronavirus
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
818-823Subventions
Organisme : NIAID NIH HHS
ID : P01 AI110657
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132317
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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