The effect of percutaneous drainage using tiny incisions on the inflammatory factors in chronic venous insufficiency combined with lipodermatosclerosis of the lower extremities.
COL1A1
Chronic venous insufficiency in the lower extremities
efficacy
inflammatory response
lipodystrophy syndrome
Journal
American journal of translational research
ISSN: 1943-8141
Titre abrégé: Am J Transl Res
Pays: United States
ID NLM: 101493030
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
11
2020
accepted:
24
12
2020
entrez:
21
5
2021
pubmed:
22
5
2021
medline:
22
5
2021
Statut:
epublish
Résumé
To explore the efficacy of percutaneous drainage with tiny incisions in chronic venous insufficiency (CVI) combined with lipodystrophy syndrome (LDS) of the lower extremities and its effect on the inflammatory factors. Sixty patients with CVI and LDS hospitalized for surgical treatment in Jiading District Central Hospital were recruited as the study cohort and randomly divided into a control group and an experimental group. The control group (n = 30) underwent varicose vein stripping in the lower extremities, while the experimental group (n = 30) was additionally treated with percutaneous drainage with tiny incisions for LDS. The efficacy of the two treatments, the mRNA expressions of collagen type I alpha 1 chain 1 (COL1A1), the lower limb circumferences, the subcutaneous thicknesses, the transcutaneous partial pressure of oxygen (TcPO The total effective rate in the experimental group was 93.33% (28/30), which was higher than the rate of 73.33% (22/30) in the control group ( Percutaneous drainage with tiny incisions has a high efficacy for CVI with LDS, and it can relieve the condition, inhibit the expression of adhesion molecules as well as the inflammatory response, improve the microcirculation of the lower extremities, reduce COL1A1 expression, and improve the quality of life.
Types de publication
Journal Article
Langues
eng
Pagination
2635-2643Informations de copyright
AJTR Copyright © 2021.
Déclaration de conflit d'intérêts
None.
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