Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction.
SMPD1
exosomes
lysosomes
placenta
preeclampsia
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
01
2021
accepted:
06
04
2021
entrez:
21
5
2021
pubmed:
22
5
2021
medline:
22
5
2021
Statut:
epublish
Résumé
Aberrant ceramide build-up in preeclampsia, a serious disorder of pregnancy, causes exuberant autophagy-mediated trophoblast cell death. The significance of ceramide accumulation for lysosomal biogenesis in preeclampsia is unknown. Here we report that lysosome formation is markedly increased in trophoblast cells of early-onset preeclamptic placentae, in particular in syncytiotrophoblasts. This is accompanied by augmented levels of transcription factor EB (TFEB).
Identifiants
pubmed: 34017832
doi: 10.3389/fcell.2021.652651
pmc: PMC8130675
doi:
Types de publication
Journal Article
Langues
eng
Pagination
652651Subventions
Organisme : NICHD NIH HHS
ID : R01 HD089660
Pays : United States
Informations de copyright
Copyright © 2021 Ermini, Farrell, Alahari, Ausman, Park, Sallais, Melland-Smith, Porter, Edson, Nevo, Litvack, Post and Caniggia.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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