The impact of weight loss on physical function and symptoms in overweight or obese breast cancer survivors: results from POWER-remote.
Breast cancer
Obesity
Patient reported outcomes
Physical function
Journal
Journal of cancer survivorship : research and practice
ISSN: 1932-2267
Titre abrégé: J Cancer Surviv
Pays: United States
ID NLM: 101307557
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
11
01
2021
accepted:
20
04
2021
pubmed:
22
5
2021
medline:
1
6
2022
entrez:
21
5
2021
Statut:
ppublish
Résumé
In pre-planned observational analysis of the POWER-remote trial, we examined the impact of weight loss on patient-reported outcomes (PROs). We hypothesized a priori that survivors with ≥ 5% weight loss would have improved physical function (PF) at 6 months vs. those who did not. Patients with stage 0-III breast cancer who completed local therapy and chemotherapy with BMI ≥ 25 kg/m Of 94 women who completed PROs, 84 and 69 participants were evaluable at 6 and 12 months, respectively. Regardless of intervention, PF improved in those with ≥ 5% weight loss vs. those with < 5% at 6 months (4.4 vs. 0.3 points; p = 0.02) and 12 months (3.6 vs. 0 points; p = 0.04). While endocrine symptoms, fatigue, and anxiety improved at 6 months in those who lost ≥ 5%, differences were not significant vs. those who lost < 5%. There was no significant change within or between groups in sexual function, depression, or sleep. Findings at 12 months were similar, except pain improved in those losing ≥ 5%. These results support the benefits of weight loss in overweight/obese breast cancer survivors. Weight management in breast cancer survivors may improve PF.
Identifiants
pubmed: 34018096
doi: 10.1007/s11764-021-01049-z
pii: 10.1007/s11764-021-01049-z
pmc: PMC8605026
mid: NIHMS1722251
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
542-551Subventions
Organisme : NCI NIH HHS
ID : P30 CA006973
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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