Amelioration of STZ-induced nephropathy in diabetic rats by saffron hydro alcoholic extract.
Animals
Biomarkers
Crocus
/ chemistry
Diabetes Mellitus, Experimental
/ complications
Diabetic Nephropathies
/ drug therapy
Gene Expression Regulation
/ drug effects
Kidney Function Tests
Oxidative Stress
/ drug effects
Plant Extracts
/ chemistry
Rats
Streptozocin
/ adverse effects
Treatment Outcome
saffron
MDA
SOD
STZ-induced nephropathy
gene expression
Journal
Hormone molecular biology and clinical investigation
ISSN: 1868-1891
Titre abrégé: Horm Mol Biol Clin Investig
Pays: Germany
ID NLM: 101538885
Informations de publication
Date de publication:
21 May 2021
21 May 2021
Historique:
received:
21
01
2021
accepted:
08
04
2021
pubmed:
22
5
2021
medline:
22
3
2022
entrez:
21
5
2021
Statut:
epublish
Résumé
Type 1 diabetes is one of the most important causes of microvascular complications such as nephropathy. On other hand, the use of herbal medicines is more affordable and has fewer side effects. Therefore, this study was conducted to assessment the therapeutic effect of In this study, we used 24 Wistar rats in four groups. To induce diabetes, we used a 55 mg/kg.bw dose of streptozotocin intraperitoneally. Type 1 diabetic rats were administered Diabetes significantly increases serum FBG, urea, creatinine and decreases albumin (p<0.001). AS well as increased the CTGF and RAGE genes expression, MDA level and decreased the SOD activity in the kidney tissue (p<0.001). Serum urea, creatinine, albumin was significantly ameliorated by The results of this study suggest that
Identifiants
pubmed: 34018383
pii: hmbci-2021-0005
doi: 10.1515/hmbci-2021-0005
doi:
Substances chimiques
Biomarkers
0
Plant Extracts
0
Streptozocin
5W494URQ81
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
411-418Informations de copyright
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
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