Direct cardiac versus systemic effects of inorganic nitrite on human left ventricular function.
HFpEF
diastolic function
inorganic nitrite
nitric oxide
pressure-volume relationship
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
pubmed:
22
5
2021
medline:
15
9
2021
entrez:
21
5
2021
Statut:
ppublish
Résumé
Inorganic nitrite is a source of nitric oxide (NO) and is considered as a potential therapy in settings where endogenous NO bioactivity is reduced and left ventricular (LV) function impaired. However, the effects of nitrite on human cardiac contractile function, and the extent to which these are direct or indirect, are unclear. We studied 40 patients undergoing diagnostic cardiac catheterization who had normal LV systolic function and were not found to have obstructive coronary disease. They received either an intracoronary sodium nitrite infusion (8.7-26 µmol/min,
Identifiants
pubmed: 34018850
doi: 10.1152/ajpheart.00081.2021
pmc: PMC8505166
doi:
Substances chimiques
Sodium Nitrite
M0KG633D4F
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
H175-H184Subventions
Organisme : British Heart Foundation
ID : CH/1999001/11735
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/18/2/34213
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R017751/1
Pays : United Kingdom
Organisme : Department of Health
ID : IS-BRC-1215-20006
Pays : United Kingdom
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