Adipocyte-specific deletion of HuR induces spontaneous cardiac hypertrophy and fibrosis.

Adipocytes / metabolism Adipose Tissue, Brown / metabolism Adipose Tissue, White / metabolism Animals Cardiomegaly / genetics ELAV-Like Protein 1 / genetics Fibrosis / genetics Mice Mice, Knockout Myocardium / metabolism
HuR adipose tissue cardiac hypertrophy cardiovascular disease fibrosis

Journal

American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228

Informations de publication

Date de publication:
01 07 2021
Historique:
pubmed: 22 5 2021
medline: 15 9 2021
entrez: 21 5 2021
Statut: ppublish

Résumé

Adipose tissue homeostasis plays a central role in cardiovascular physiology, and the presence of thermogenically active brown adipose tissue (BAT) has recently been associated with cardiometabolic health. We have previously shown that adipose tissue-specific deletion of HuR (Adipo-HuR

Identifiants

DOI: 10.1152/ajpheart.00957.2020 PMID: 34018851 PMC: PMC8321812
pubmed: 34018851
doi: 10.1152/ajpheart.00957.2020
pmc: PMC8321812
doi:

Substances chimiques

ELAV-Like Protein 1 0

Banques de données

figshare
['10.6084/m9.figshare.14567733', '10.6084/m9.figshare.14573274', '10.6084/m9.figshare.14573286', '10.6084/m9.figshare.14568483', '10.6084/m9.figshare.14568621', '10.6084/m9.figshare.14568624', '10.6084/m9.figshare.13326524', '10.6084/m9.figshare.13326659', '10.6084/m9.figshare.13326680', '10.6084/m9.figshare.13326692']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

H228-H241

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL132111
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148598
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL125204
Pays : United States

Commentaires et corrections

Type : CommentIn

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Auteurs

Adrienne R Guarnieri (AR)

Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Sarah R Anthony (SR)

Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Anamarie Gozdiff (A)

Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Lisa C Green (LC)

Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
ORCID: 0000-0002-1164-6611

Salma M Fleifil (SM)

Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Sam Slone (S)

Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Michelle L Nieman (ML)

Department of Pharmacology & Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Perwez Alam (P)

Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Joshua B Benoit (JB)

Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio.

A Phillip Owens (AP)

Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Onur Kanisicak (O)

Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
ORCID: 0000-0002-8393-4874

Michael Tranter (M)

Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › Adipocyte-specific deletion of HuR induces...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux brun › Adipocyte-specific deletion of HuR induces...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux blanc › Adipocyte-specific deletion of HuR induces...
questionsmedicales.fr › Eucaryotes › Animaux › Adipocyte-specific deletion of HuR induces...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Hypertrophie › Cardiomégalie › Adipocyte-specific deletion of HuR induces...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines à motif de reconnaissance de l'ARN › Antigènes Hu de l'encéphalomyélite paranéoplasique › Protéine-1 similaire à ELAV › Adipocyte-specific deletion of HuR induces...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Adipocyte-specific deletion of HuR induces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Adipocyte-specific deletion of HuR induces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Adipocyte-specific deletion of HuR induces...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Adipocyte-specific deletion of HuR induces...