Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low- and intermediate-grade gliomas.
cognition
low-grade glioma
pediatric brain tumor
proton radiotherapy
Journal
Pediatric blood & cancer
ISSN: 1545-5017
Titre abrégé: Pediatr Blood Cancer
Pays: United States
ID NLM: 101186624
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
12
04
2021
received:
11
03
2021
accepted:
16
04
2021
pubmed:
22
5
2021
medline:
12
3
2022
entrez:
21
5
2021
Statut:
ppublish
Résumé
The relationship between age and neurocognitive functioning following proton beam radiotherapy (PRT) in low- and intermediate-grade gliomas (LIGG) has yet to be examined. Eighteen LIGG patients treated with PRT were prospectively enrolled and received annual neurocognitive evaluations of perceptual/verbal reasoning, working memory, and processing speed postradiotherapy. The median age at diagnosis was 8.2 years (range 1.0-14.7) and the median age at PRT was 9.9 years (range 4.2-17.0). Patients' neurocognitive performance did not change on any measure following PRT (p ≥ .142). We did not observe significant changes in cognitive function over time among a small group of LIGG patients treated with PRT.
Identifiants
pubmed: 34019329
doi: 10.1002/pbc.29096
pmc: PMC9040342
mid: NIHMS1794860
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e29096Subventions
Organisme : NCI NIH HHS
ID : K07 CA157923
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA187202
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
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