Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.
Animals
Antibodies, Neutralizing
/ immunology
B-Lymphocytes
/ immunology
Broadly Neutralizing Antibodies
/ immunology
COVID-19
/ immunology
Dimerization
Epitopes
/ immunology
Glycosylation
HIV Antibodies
/ immunology
HIV Infections
/ immunology
HIV-1
/ immunology
Humans
Immunoglobulin Fab Fragments
/ chemistry
Macaca mulatta
Polysaccharides
/ chemistry
Receptors, Antigen, B-Cell
/ chemistry
SARS-CoV-2
/ immunology
Simian Immunodeficiency Virus
/ genetics
Spike Glycoprotein, Coronavirus
/ immunology
Vaccines
/ immunology
env Gene Products, Human Immunodeficiency Virus
/ chemistry
FDG Abs
Fab dimerization
HIV-1 Env glycans
IgM-memory B cells
SARS-CoV-2 spike glycans
glycan-dependent Ab binding
marginal zone B cells
natural Abs
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
27 05 2021
27 05 2021
Historique:
received:
11
12
2020
revised:
22
03
2021
accepted:
23
04
2021
pubmed:
22
5
2021
medline:
9
6
2021
entrez:
21
5
2021
Statut:
ppublish
Résumé
Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated HIV-1 envelope (Env) as a model antigen. 2G12 is a broadly neutralizing Ab (bnAb) that targets a conserved glycan patch on Env of geographically diverse HIV-1 strains using a unique heavy-chain (V
Identifiants
pubmed: 34019795
pii: S0092-8674(21)00577-8
doi: 10.1016/j.cell.2021.04.042
pmc: PMC8135257
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Broadly Neutralizing Antibodies
0
Epitopes
0
HIV Antibodies
0
Immunoglobulin Fab Fragments
0
Polysaccharides
0
Receptors, Antigen, B-Cell
0
Spike Glycoprotein, Coronavirus
0
Vaccines
0
env Gene Products, Human Immunodeficiency Virus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2955-2972.e25Subventions
Organisme : NIAID NIH HHS
ID : UM1 AI100645
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM136577
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201800004C
Pays : United States
Organisme : NIAID NIH HHS
ID : UC6 AI058607
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140897
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131251
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI165080
Pays : United States
Organisme : NIGMS NIH HHS
ID : U24 GM129539
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI120801
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007171
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI131331
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI160607
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145687
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI128832
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests B.A. and W.E.W. are co-founders of Chemitope Technologies, and G.M.L. is a founder of Avidea Technologies that now commercially produce peptides used in our HIV-1 vaccination regimen. The remaining authors declare no competing interests.
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