IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent.
Adult
Allergens
/ immunology
Antigens, Dermatophagoides
/ immunology
Cytokines
/ immunology
Humans
Immunity, Innate
Lymphocytes
/ immunology
Mutation
Nod2 Signaling Adaptor Protein
/ genetics
Skin
/ immunology
Staphylococcal Infections
/ immunology
Staphylococcus aureus
Toll-Like Receptor 2
/ immunology
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
21 05 2021
21 05 2021
Historique:
received:
26
08
2020
revised:
26
02
2021
accepted:
21
04
2021
entrez:
22
5
2021
pubmed:
23
5
2021
medline:
5
3
2022
Statut:
ppublish
Résumé
Cutaneous group 2 innate lymphoid cells (ILC2) are spatially and epigenetically poised to respond to barrier compromise and associated immunological threats. ILC2, lacking rearranged antigen-specific receptors, are primarily activated by damage-associated cytokines and respond with type 2 cytokine production. To investigate ILC2 potential for direct sensing of skin pathogens and allergens, we performed RNA sequencing of ILC2 derived from in vivo challenged human skin or blood. We detected expression of
Identifiants
pubmed: 34021026
pii: 6/59/eabe5084
doi: 10.1126/sciimmunol.abe5084
pmc: PMC7611333
mid: EMS130401
pii:
doi:
Substances chimiques
Allergens
0
Antigens, Dermatophagoides
0
Cytokines
0
NOD2 protein, human
0
Nod2 Signaling Adaptor Protein
0
TLR2 protein, human
0
Toll-Like Receptor 2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : U105178805
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U105178805
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00008/7
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00008/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12010/7
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K018779/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S036377/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 090532/Z/09/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 090532
Pays : United Kingdom
Organisme : Medical Research Council
ID : CF7720
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_MR/S025952/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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