Transcriptional signature in microglia associated with Aβ plaque phagocytosis.
Aged
Aged, 80 and over
Alzheimer Disease
/ metabolism
Animals
Brain
/ metabolism
Disease Models, Animal
Female
Gene Expression
Gene Regulatory Networks
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
/ metabolism
Male
Mice
Microglia
/ metabolism
Middle Aged
Phagocytosis
/ physiology
Plaque, Amyloid
/ genetics
Transcriptome
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
21 05 2021
21 05 2021
Historique:
received:
16
11
2019
accepted:
13
04
2021
entrez:
22
5
2021
pubmed:
23
5
2021
medline:
12
6
2021
Statut:
epublish
Résumé
The role of microglia cells in Alzheimer's disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (using labelling with methoxy-XO4, XO4
Identifiants
pubmed: 34021136
doi: 10.1038/s41467-021-23111-1
pii: 10.1038/s41467-021-23111-1
pmc: PMC8140091
doi:
Substances chimiques
Hif1a protein, mouse
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3015Références
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