Fluorescence Fluctuation Spectroscopy enables quantification of potassium channel subunit dynamics and stoichiometry.

Action Potentials Animals CHO Cells Cricetulus Humans Ion Channel Gating Models, Molecular Molecular Conformation Patch-Clamp Techniques Potassium Channels / chemistry Protein Binding Protein Interaction Domains and Motifs Spectrum Analysis / methods Structure-Activity Relationship

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
21 05 2021
Historique:
received: 04 12 2020
accepted: 15 04 2021
entrez: 22 5 2021
pubmed: 23 5 2021
medline: 5 11 2021
Statut: epublish

Résumé

Voltage-gated potassium (Kv) channels are a family of membrane proteins that facilitate K

Identifiants

DOI: 10.1038/s41598-021-90002-2 PMID: 34021177 PMC: PMC8140153
pubmed: 34021177
doi: 10.1038/s41598-021-90002-2
pii: 10.1038/s41598-021-90002-2
pmc: PMC8140153
doi:

Substances chimiques

Potassium Channels 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

10719

Subventions

Organisme : NIGMS NIH HHS
ID : P41 GM103540
Pays : United States
Organisme : NIDCD NIH HHS
ID : R21 DC015736
Pays : United States

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Auteurs

Giulia Tedeschi (G)

Department of Biomedical Engineering, Laboratory for Fluorescence Dynamics, University of California Irvine, Irvine, CA, 92697, USA.

Lorenzo Scipioni (L)

Department of Biomedical Engineering, Laboratory for Fluorescence Dynamics, University of California Irvine, Irvine, CA, 92697, USA.

Maria Papanikolaou (M)

Department of Physiology and Biophysics, Bioelectricity Laboratory, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA.

Geoffrey W Abbott (GW)

Department of Physiology and Biophysics, Bioelectricity Laboratory, School of Medicine, University of California Irvine, Irvine, CA, 92697, USA. abbottg@uci.edu.

Michelle A Digman (MA)

Department of Biomedical Engineering, Laboratory for Fluorescence Dynamics, University of California Irvine, Irvine, CA, 92697, USA. mdigman@uci.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Eucaryotes › Animaux › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Cricetulus › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes électrophysiologiques › Ouverture et fermeture des portes des canaux ioniques › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Techniques de patch-clamp › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Motifs et domaines d'intéraction protéique › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Fluorescence Fluctuation Spectroscopy enables...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Fluorescence Fluctuation Spectroscopy enables...