Retinal ganglion cells projecting to superior colliculus and pulvinar in marmoset.
Lateral geniculate nucleus
Pretectum
Primate retina
Pulvinar
Retinal ganglion cell projections
Superior colliculus
Journal
Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
17
02
2021
accepted:
08
05
2021
pubmed:
23
5
2021
medline:
21
12
2021
entrez:
22
5
2021
Statut:
ppublish
Résumé
We determined the retinal ganglion cell types projecting to the medial subdivision of inferior pulvinar (PIm) and the superior colliculus (SC) in the common marmoset monkey, Callithrix jacchus. Adult marmosets received a bidirectional tracer cocktail into the PIm (conjugated to Alexa fluor 488), and the SC (conjugated to Alexa fluor 594) using an MRI-guided approach. One SC injection included the pretectum. The large majority of retrogradely labelled cells were obtained from SC injections, with only a small proportion obtained after PIm injections. Retrogradely labelled cells were injected intracellularly in vitro using lipophilic dyes (DiI, DiO). The SC and PIm both received input from a variety of ganglion cell types. Input to the PIm was dominated by broad thorny (41%), narrow thorny (24%) and large bistratified (25%) ganglion cells. Input to the SC was dominated by parasol (37%), broad thorny (24%) and narrow thorny (17%) cells. Midget ganglion cells (which make up the large majority of primate retinal ganglion cells) and small bistratified (blue-ON/yellow OFF) cells were never observed to project to SC or PIm. Small numbers of other wide-field ganglion cell types were also encountered. Giant sparse (presumed melanopsin-expressing) cells were only seen following the tracer injection which included the pretectum. We note that despite the location of pulvinar complex in dorsal thalamus, and its increased size and functional importance in primate evolution, the retinal projections to pulvinar have more in common with SC projections than they do with projections to the dorsal lateral geniculate nucleus.
Identifiants
pubmed: 34021395
doi: 10.1007/s00429-021-02295-8
pii: 10.1007/s00429-021-02295-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2745-2762Subventions
Organisme : National Health and Medical Research Council
ID : APP1123418
Organisme : National Health and Medical Research Council
ID : APP1042893
Organisme : National Health and Medical Research Council
ID : APP1077677
Organisme : Centre of Excellence for Integrative Brain Function, Australian Research Council
ID : CE140100007
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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