Chlormethine Gel for the Treatment of Skin Lesions in All Stages of Mycosis Fungoides Cutaneous T-Cell Lymphoma: A Narrative Review and International Experience.
Chlormethine gel
Cutaneous T-cell lymphoma
Mycosis fungoides
Patient management
Real-world
Journal
Dermatology and therapy
ISSN: 2193-8210
Titre abrégé: Dermatol Ther (Heidelb)
Pays: Switzerland
ID NLM: 101590450
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
26
02
2021
pubmed:
23
5
2021
medline:
23
5
2021
entrez:
22
5
2021
Statut:
ppublish
Résumé
Mycosis fungoides (MF), the most common form of primary cutaneous T-cell lymphoma, is a disease typically with an indolent course that is initially characterized by localized patches and plaques. In the early stages of the disease, treatment involves skin-directed therapies (SDTs) such as topical corticosteroids and retinoids. Chlormethine gel (also known as mechlorethamine) was the first SDT purposely developed to treat MF and is currently endorsed by international guidelines for the treatment of adult patients with MF as a first-line therapy. While chlormethine is an efficacious therapy, its usage may be complicated by the development of cutaneous reactions at the sites of application. Herein, we discuss the supportive guidelines for MF and the suitability of chlormethine as a therapeutic option in patients with MF. In addition, we present real-world experience on the use of chlormethine gel from clinics in the USA, Israel, and France with the aim of demonstrating the efficacy of chlormethine gel in routine clinical practice and outlining strategies that are being used to manage emergent cutaneous reactions.
Identifiants
pubmed: 34021485
doi: 10.1007/s13555-021-00539-3
pii: 10.1007/s13555-021-00539-3
pmc: PMC8322195
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1085-1106Informations de copyright
© 2021. The Author(s).
Références
Blood. 1996 Oct 1;88(7):2385-409
pubmed: 8839829
Arch Dermatol. 2002 Mar;138(3):325-32
pubmed: 11902983
Cutis. 1980 Feb;25(2):155-7, 160-1
pubmed: 6153595
Br J Dermatol. 2019 Mar;180(3):496-526
pubmed: 30561020
J Am Acad Dermatol. 1989 Mar;20(3):416-28
pubmed: 2537348
Acta Derm Venereol. 1985;65(1):53-8
pubmed: 2578706
Food Chem Toxicol. 2014 Oct;72:40-50
pubmed: 25016034
Arch Dermatol. 2003 Jul;139(7):857-66
pubmed: 12873880
J Clin Oncol. 1987 Nov;5(11):1796-803
pubmed: 3681368
Curr Top Med Chem. 2017;17(10):1157-1176
pubmed: 27697046
Int J Pharm. 2008 Oct 1;362(1-2):67-73
pubmed: 18634862
Chin Clin Oncol. 2019 Feb;8(1):7
pubmed: 30525757
Cancer. 1977 Dec;40(6):2851-3
pubmed: 412580
Arch Dermatol. 1995 Apr;131(4):432-5
pubmed: 7726585
Arch Dermatol. 2003 Feb;139(2):165-73
pubmed: 12588222
J Clin Oncol. 2001 Feb 1;19(3):779-84
pubmed: 11157031
Int J Health Sci (Qassim). 2013 Jun;7(2):220-39
pubmed: 24421750
JAMA Dermatol. 2013 Jan;149(1):25-32
pubmed: 23069814
Cancer Treat Rep. 1979 Apr;63(4):681-9
pubmed: 109206
Eur J Cancer. 2017 May;77:57-74
pubmed: 28365528
Chin Clin Oncol. 2019 Feb;8(1):13
pubmed: 30525753
Melanoma Manag. 2017 Mar;4(1):13-37
pubmed: 28758010
Curr Opin Oncol. 2015 Mar;27(2):128-33
pubmed: 25594623
J Clin Aesthet Dermatol. 2009 Jun;2(6):22-7
pubmed: 20729945
J Dermatol. 2020 May;47(5):546-550
pubmed: 32100361
J Clin Oncol. 2015 Nov 10;33(32):3766-73
pubmed: 26438120
J Am Acad Dermatol. 1988 Oct;19(4):684-91
pubmed: 3183094
Br J Dermatol. 2002 Nov;147(5):926-30
pubmed: 12410702
J Am Acad Dermatol. 1999 Mar;40(3):418-25
pubmed: 10071312
Arch Dermatol. 1999 Nov;135(11):1349-53
pubmed: 10566833
J Eur Acad Dermatol Venereol. 2013 Feb;27(2):163-8
pubmed: 22229501
Arch Dermatol. 2000 Apr;136(4):504-10
pubmed: 10768649
Cancer. 1983 Dec 15;52(12):2214-9
pubmed: 6640491
Am J Clin Dermatol. 2021 May;22(3):407-414
pubmed: 33656660
AAPS PharmSciTech. 2018 Nov;19(8):3512-3533
pubmed: 30421383
Br J Dermatol. 1978 Jul;99(1):61-3
pubmed: 678466
Arch Dermatol. 1984 Dec;120(12):1585-90
pubmed: 6508330
J Invest Dermatol. 1998 Jun;110(6):946-50
pubmed: 9620303
J Am Acad Dermatol. 2020 Sep;83(3):928-930
pubmed: 32089294
Br J Dermatol. 2014 Mar;170(3):699-704
pubmed: 24024659
Arch Dermatol. 1998 Aug;134(8):949-54
pubmed: 9722724
Arch Dermatol. 2005 Sep;141(9):1117-20
pubmed: 16172308
Ann Oncol. 2018 Oct 1;29(Suppl 4):iv30-iv40
pubmed: 29878045