Pharmacogenetic association of diabetes-associated genetic risk score with rapid progression of coronary artery calcification following treatment with HMG-CoA-reductase inhibitors -results of the Heinz Nixdorf Recall Study.
Aged
Coronary Artery Disease
/ drug therapy
Diabetes Mellitus, Type 2
/ epidemiology
Disease Progression
Female
Genetic Predisposition to Disease
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/ pharmacology
Male
Middle Aged
Pharmacogenetics
Polymorphism, Single Nucleotide
Risk Factors
Tomography, X-Ray Computed
Vascular Calcification
/ drug therapy
Cohort study
Diabetes mellitus
Genetic risk score
HMG-CoA-reductase inhibitors
Pleiotropic effects
Progression of coronary artery calcification
Journal
Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 1432-1912
Titre abrégé: Naunyn Schmiedebergs Arch Pharmacol
Pays: Germany
ID NLM: 0326264
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
19
03
2021
accepted:
06
05
2021
pubmed:
23
5
2021
medline:
11
1
2022
entrez:
22
5
2021
Statut:
ppublish
Résumé
HMG-CoA-Reductase inhibitors (HMGRIs) are currently the most widely used group of drugs in patients with coronary artery disease (CAD) and are given preemptively to patients with high levels of cholesterol, including those with diabetes mellitus (DM). However, intake of HMGRIs also increases the progression of coronary artery calcification (CAC) and the risk of developing DM. This study aimed to investigate whether HMGRI intake interacts with the diabetes-associated genetic risk score (GRS) to affect CAC progression using data from the population-based Heinz Nixdorf Recall (HNR) study. CAC was measured in 3157 participants using electron-beam computed tomography twice, at baseline (CAC
Identifiants
pubmed: 34021798
doi: 10.1007/s00210-021-02100-7
pii: 10.1007/s00210-021-02100-7
pmc: PMC8298241
doi:
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1713-1725Informations de copyright
© 2021. The Author(s).
Références
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