Hollow organic/inorganic hybrid nanoparticles from dextran-block-polypeptide copolymer: Double click reaction synthesis and properties.
Block copolymer
Double click reaction
Hybrid nanoparticles
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
30 Jun 2021
30 Jun 2021
Historique:
received:
02
04
2021
revised:
08
05
2021
accepted:
15
05
2021
pubmed:
23
5
2021
medline:
22
7
2021
entrez:
22
5
2021
Statut:
ppublish
Résumé
To increase the drug loading and prolong the drug release time, novel hollow organic/inorganic hybrid nanoparticles based on dextran-b-poly(L-glutamate-graft-3-mercaptopropyltrimethoxysilane) (Dex-b-P(ALG-g-MTPMS)) were prepared. First, a polysaccharide block polypeptide diblock copolymer, dextran-block-poly(γ-allyl-L-glutamate) (Dex-b-PALG) bearing allyl side-groups, has been synthesized by the combination of ring-opening polymerization and alkyne-azide [2 + 3] Huisgen's cycloaddition. Next, the allyl side-groups residing in the poly(γ-allyl-L-glutamate) block were further functionalized with 3-mercaptopropyltrimethoxysilane(MPTMS) by radical "thiol-ene" addition reactions. Finally, after a sol-gel process of the obtained copolymers, the novel organic/inorganic hybrid nanoparticles were prepared. The molecular structures, physicochemical, and self-assembly of these copolymers were characterized through FTIR,
Identifiants
pubmed: 34022305
pii: S0141-8130(21)01076-X
doi: 10.1016/j.ijbiomac.2021.05.101
pii:
doi:
Substances chimiques
Dextrans
0
Drug Carriers
0
Organosilicon Compounds
0
Peptides
0
Polymers
0
Sulfhydryl Compounds
0
(3-mercaptopropyl)trimethoxysilane
8CB1M08OIW
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1243-1253Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest.