Central residues of FSHβ (89-97) peptide are not critical for FSHR binding: Implications for peptidomimetic design.

Animals Binding Sites / drug effects Drug Design Female Follicle Stimulating Hormone / chemistry Humans Models, Molecular Ovary / drug effects Peptides / chemistry Peptidomimetics Receptors, FSH / antagonists & inhibitors
Follicle stimulating hormone MD simulation Ovary Peptide docking Steelman-Pohley assay

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
15 07 2021
Historique:
received: 22 02 2021
revised: 14 05 2021
accepted: 16 05 2021
pubmed: 23 5 2021
medline: 6 1 2022
entrez: 22 5 2021
Statut: ppublish

Résumé

In our previous study, we had identified a 9-mer peptide (FSHβ (89-97)) derived from seat belt loop of human FSHβ and demonstrated its ability to function as FSHR antagonist in vivo. Structure analysis revealed that the four central residues

Identifiants

DOI: 10.1016/j.bmcl.2021.128132 PMID: 34022413
pubmed: 34022413
pii: S0960-894X(21)00358-9
doi: 10.1016/j.bmcl.2021.128132
pii:
doi:

Substances chimiques

Peptides 0
Peptidomimetics 0
Receptors, FSH 0
Follicle Stimulating Hormone 9002-68-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

128132

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Kaushiki S Prabhudesai (KS)

Biomedical Informatics Centre, ICMR-National Institute for Research in Reproductive Health, Mumbai 400012, Maharashtra, India.

Sahil Raje (S)

Biomedical Informatics Centre, ICMR-National Institute for Research in Reproductive Health, Mumbai 400012, Maharashtra, India.

Karishma Desai (K)

Biomedical Informatics Centre, ICMR-National Institute for Research in Reproductive Health, Mumbai 400012, Maharashtra, India.

Deepak Modi (D)

Molecular and Cellular Biology Laboratory, ICMR-National Institute for Research in Reproductive Health, JM Street, Parel, Mumbai 400012, Maharashtra, India.

Vikas Dighe (V)

National Center for Preclinical Reproductive and Genetic Toxicology, ICMR-National Institute for Research in Reproductive Health, Mumbai 400012, Maharashtra, India.

Alessandro Contini (A)

Dipartimento di Scienze Farmaceutiche - Sezione di Chimica Generale e Organica "Alessandro Marchesini", Università degli Studi di Milano, Via Venezian, 21, 20133 Milano, Italy.

Susan Idicula-Thomas (S)

Biomedical Informatics Centre, ICMR-National Institute for Research in Reproductive Health, Mumbai 400012, Maharashtra, India. Electronic address: thomass@nirrh.res.in.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Central residues of FSHβ (89-97) peptide are...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Central residues of FSHβ (89-97) peptide are...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Central residues of FSHβ (89-97) peptide are...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Gonadotrophines hypophysaires › Hormone folliculostimulante › Central residues of FSHβ (89-97) peptide are...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Central residues of FSHβ (89-97) peptide are...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Central residues of FSHβ (89-97) peptide are...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Gonades › Ovaire › Central residues of FSHβ (89-97) peptide are...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Central residues of FSHβ (89-97) peptide are...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Peptidomimétiques › Central residues of FSHβ (89-97) peptide are...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur gonadotrophine › Récepteur FSH › Central residues of FSHβ (89-97) peptide are...