Membrane shape remodeling by protein crowding.
Journal
Biophysical journal
ISSN: 1542-0086
Titre abrégé: Biophys J
Pays: United States
ID NLM: 0370626
Informations de publication
Date de publication:
15 06 2021
15 06 2021
Historique:
received:
22
10
2020
revised:
19
04
2021
accepted:
20
04
2021
pubmed:
24
5
2021
medline:
3
7
2021
entrez:
23
5
2021
Statut:
ppublish
Résumé
The steric repulsion between proteins on biological membranes is one of the most generic mechanisms that cause membrane shape changes. We present a minimal model in which a spontaneous curvature is induced by asymmetric protein crowding. Our results show that the interplay between the induced spontaneous curvature and the membrane tension determines the energy-minimizing shapes, which describes the wide range of experimentally observed membrane shapes, i.e., flat membranes, spherical vesicles, elongated tubular protrusions, and pearling structures. Moreover, the model gives precise predictions on how membrane shape changes by protein crowding can be tuned by controlling the protein size, the density of proteins, and the size of the crowded domain.
Identifiants
pubmed: 34023296
pii: S0006-3495(21)00368-4
doi: 10.1016/j.bpj.2021.04.029
pmc: PMC8390870
pii:
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2482-2489Informations de copyright
Copyright © 2021 Biophysical Society. Published by Elsevier Inc. All rights reserved.
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