Immunity to hepatitis A virus in liver transplant recipients: A population-based study in Iran.
Acute Disease
Adolescent
Adult
Age Factors
Aged
Child
Cross-Sectional Studies
Educational Status
Female
Hepatitis A
/ immunology
Hepatitis A Antibodies
/ analysis
Hepatitis A virus
/ immunology
Humans
Iran
Liver Transplantation
/ statistics & numerical data
Logistic Models
Male
Middle Aged
Residence Characteristics
Sex Factors
Social Class
Transplant Recipients
Water Supply
Young Adult
Hepatitis A
Immunity
Inmunidad
Liver transplantation
Trasplante de hígado
Journal
Gastroenterologia y hepatologia
ISSN: 0210-5705
Titre abrégé: Gastroenterol Hepatol
Pays: Spain
ID NLM: 8406671
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
02
10
2020
revised:
05
03
2021
accepted:
29
03
2021
pubmed:
24
5
2021
medline:
15
2
2022
entrez:
23
5
2021
Statut:
ppublish
Résumé
Acute hepatitis A is usually a self-limited viral disease but can be severe and even fatal in special groups of patients including those with chronic liver disease and recipients of liver transplantation. To take appropriate preventive measures, it is important to determine the immune status against the hepatitis A virus in patients at risk of grave clinical outcomes following infection. To assess the need for immunization against hepatitis A, we aimed to determine the immune status against hepatitis A in a population of liver transplant recipients. We also investigated the association between hepatitis A immune status and demographic factors such as age and sex, underlying liver disease, source of drinking water, geographical area of residence and socioeconomic status. This cross-sectional study was performed on 242 recipients of allogenic liver transplants at Abu Ali Sina Organ Transplant Hospital in Shiraz, Iran, between January 2017 and April 2017. The level of immunity was assessed using hepatitis A antibody detection kits. The rate of immunity against hepatitis A was detected as 88.8% in our study population. In the multivariable logistic regression model, younger age (OR=1.175, P<0.001) and higher education level (OR=2.142, P=0.040) were the main determinants of non-immune status. However, hepatitis A immunity was independent of gender, monthly family income, water supply source, residential area and underlying liver disorder. Although a significant proportion of liver transplant recipients in this study showed evidence of natural immunity to hepatitis A, a considerable proportion of younger patients and those with a higher level of education were non-immune. The results of this study signify the importance of screening for hepatitis A immunity in this at-risk population of patients and the need for vaccinating non-immune patients.
Sections du résumé
BACKGROUND
BACKGROUND
Acute hepatitis A is usually a self-limited viral disease but can be severe and even fatal in special groups of patients including those with chronic liver disease and recipients of liver transplantation. To take appropriate preventive measures, it is important to determine the immune status against the hepatitis A virus in patients at risk of grave clinical outcomes following infection. To assess the need for immunization against hepatitis A, we aimed to determine the immune status against hepatitis A in a population of liver transplant recipients. We also investigated the association between hepatitis A immune status and demographic factors such as age and sex, underlying liver disease, source of drinking water, geographical area of residence and socioeconomic status.
METHODS
METHODS
This cross-sectional study was performed on 242 recipients of allogenic liver transplants at Abu Ali Sina Organ Transplant Hospital in Shiraz, Iran, between January 2017 and April 2017. The level of immunity was assessed using hepatitis A antibody detection kits.
RESULTS
RESULTS
The rate of immunity against hepatitis A was detected as 88.8% in our study population. In the multivariable logistic regression model, younger age (OR=1.175, P<0.001) and higher education level (OR=2.142, P=0.040) were the main determinants of non-immune status. However, hepatitis A immunity was independent of gender, monthly family income, water supply source, residential area and underlying liver disorder.
CONCLUSION
CONCLUSIONS
Although a significant proportion of liver transplant recipients in this study showed evidence of natural immunity to hepatitis A, a considerable proportion of younger patients and those with a higher level of education were non-immune. The results of this study signify the importance of screening for hepatitis A immunity in this at-risk population of patients and the need for vaccinating non-immune patients.
Identifiants
pubmed: 34023475
pii: S0210-5705(21)00150-3
doi: 10.1016/j.gastrohep.2021.03.008
pii:
doi:
Substances chimiques
Hepatitis A Antibodies
0
Types de publication
Journal Article
Langues
eng
spa
Sous-ensembles de citation
IM
Pagination
99-105Informations de copyright
Copyright © 2021 Elsevier España, S.L.U. All rights reserved.