Drug combination therapy for emerging viral diseases.
COVID-19
Drug combination therapy
Emerging viral diseases
SARS-CoV-2
Journal
Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
25
02
2021
revised:
14
04
2021
accepted:
16
05
2021
pubmed:
24
5
2021
medline:
29
10
2021
entrez:
23
5
2021
Statut:
ppublish
Résumé
Effective therapeutics to combat emerging viral infections are an unmet need. Historically, treatments for chronic viral infections with single drugs have not been successful, as exemplified by human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections. Combination therapy for these diseases has led to improved clinical outcomes with dramatic reductions in viral load, morbidity, and mortality. Drug combinations can enhance therapeutic efficacy through additive, and ideally synergistic, effects for emerging and re-emerging viruses, such as influenza, severe acute respiratory syndrome-coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS)-CoV, Ebola, Zika, and SARS-coronavirus 2 (CoV-2). Although novel drug development through traditional pipelines remains a priority, in the interim, effective synergistic drug candidates could be rapidly identified by drug-repurposing screens, facilitating accelerated paths to clinical testing and potential emergency use authorizations.
Identifiants
pubmed: 34023496
pii: S1359-6446(21)00240-3
doi: 10.1016/j.drudis.2021.05.008
pmc: PMC8139175
mid: NIHMS1717427
pii:
doi:
Substances chimiques
Antiviral Agents
0
Drug Combinations
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2367-2376Subventions
Organisme : Intramural NIH HHS
ID : ZIA TR000018
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
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