Helicobacter pylori Infection.

Helicobacter Infections / diagnosis Helicobacter pylori Humans Peptic Ulcer Stomach Neoplasms
Antibiotic resistance Diagnosis Gastric cancer Helicobacter pylori Microbial pathogenesis Peptic ulcer

Journal

Gastroenterology clinics of North America
ISSN: 1558-1942
Titre abrégé: Gastroenterol Clin North Am
Pays: United States
ID NLM: 8706257

Informations de publication

Date de publication:
06 2021
Historique:
entrez: 24 5 2021
pubmed: 25 5 2021
medline: 26 10 2021
Statut: ppublish

Résumé

Helicobacter pylori infection remains one of the most prevalent infections worldwide, causing significant morbidity and mortality from gastric malignancies and peptic ulcers. This article provides a summary of the microbiology and pathogenesis of this bacterium, emphasizing the complex and protean effects of H pylori on gastric epithelial cells, including stem and progenitor populations, and evasion of host immune defenses. Increasing antibiotic resistance has made management more challenging. This article discusses the appropriate diagnostic modality for different clinical scenarios, and the evolving treatment of H pylori infections, including the use of antibiotic susceptibility testing to aid regimen selection.

Identifiants

DOI: 10.1016/j.gtc.2021.02.001 PMID: 34024441
pubmed: 34024441
pii: S0889-8553(21)00013-3
doi: 10.1016/j.gtc.2021.02.001
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

261-282

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure S.F. Moss has served on the advisory boards of Redhill Biopharma and Phathom Pharmaceuticals, performs research sponsored by American Molecular Labs, and is a consultant to Takeda. The other authors have nothing to disclose.

Auteurs

Jaehoon Cho (J)

Division of Gastroenterology, Brown University, 593 Eddy Street, POB 240, Providence, RI 02903, USA.

Akriti Prashar (A)

Department of Gastroenterology, Hepatology and Nutrition, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Cell Biology Program, The Hospital for Sick Children, 686 Bay Street, Toronto, Ontario M5G0A4, Canada.

Nicola L Jones (NL)

Department of Gastroenterology, Hepatology and Nutrition, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Cell Biology Program, The Hospital for Sick Children, 686 Bay Street, Toronto, Ontario M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.

Steven F Moss (SF)

Division of Gastroenterology, Brown University, 593 Eddy Street, POB 240, Providence, RI 02903, USA. Electronic address: Steven_Moss@brown.edu.

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Classifications MeSH

questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Helicobacter › Helicobacter pylori Infection.
questionsmedicales.fr › Bactéries › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori › Helicobacter pylori Infection.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Helicobacter pylori Infection.
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Ulcère peptique › Helicobacter pylori Infection.
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Tumeurs de l'estomac › Helicobacter pylori Infection.