An Evaluation of the Safety and Feasibility of Adenosine-assisted Clipping Surgery for Unruptured Cerebral Aneurysms: Study Protocol.
adenosine
clipping
unruptured cerebral aneurysm
Journal
Neurologia medico-chirurgica
ISSN: 1349-8029
Titre abrégé: Neurol Med Chir (Tokyo)
Pays: Japan
ID NLM: 0400775
Informations de publication
Date de publication:
15 Jul 2021
15 Jul 2021
Historique:
pubmed:
25
5
2021
medline:
29
10
2021
entrez:
24
5
2021
Statut:
ppublish
Résumé
The effectiveness of adenosine-induced flow arrest in surgical clipping for the cerebral aneurysms with difficulties in temporary clip placement to the proximal main trunk has been reported. This is the first clinical trial to evaluate the safety and feasibility of adenosine-assisted clipping surgery for unruptured cerebral aneurysms (UCAs) in Japan. The inclusion criteria are as follows: patients over 20 years old, patients who agree to be enrolled in this study after providing informed consent, patients who undergo clipping surgery for UCA in our institute, and patients in whom the surgeons (T.H. or I.D.) judge that decompression of the aneurysm is effective. The primary endpoint is a modified Rankin Scale (mRS) score 30 days after surgery. We plan to enroll 10 patients in this study. The original protocol of adenosine administration was established in this trial. Herein, we present the study protocol.
Identifiants
pubmed: 34024879
doi: 10.2176/nmc.st.2021-0018
pmc: PMC8280325
doi:
Substances chimiques
Adenosine
K72T3FS567
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
393-396Références
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