Reactions of kynurenic acid with hypobromous acid and hypochlorous acid.
eosinophil peroxidase
hypobromous acid
hypochlorous acid
kynurenic acid
myeloperoxidase
Journal
Journal of clinical biochemistry and nutrition
ISSN: 0912-0009
Titre abrégé: J Clin Biochem Nutr
Pays: Japan
ID NLM: 8700907
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
14
04
2020
accepted:
31
08
2020
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
25
5
2021
Statut:
ppublish
Résumé
Kynurenic acid, a tryptophan metabolite, acts as antagonist or agonist of several receptors. Hypobromous acid (HOBr) and hypochlorous acid (HOCl) are generated by eosinophils and neutrophils. At inflammation sites, kynurenic acid may encounter HOBr and HOCl to generate products. When kynurenic acid was incubated with HOBr under neutral conditions, kynurenic acid generated a single product almost exclusively. This was identified as 3-bromokynurenic acid. Kynurenic acid reacted with HOCl, generating two products. The major product was identified as 3-chlorokynurenic acid with its oxidative decarboxylation product, 3-chloro-4-hydroxy-2(1
Identifiants
pubmed: 34025023
doi: 10.3164/jcbn.20-62
pii: DN/JST.JSTAGE/jcbn/20-62
pmc: PMC8129975
doi:
Types de publication
Journal Article
Langues
eng
Pagination
215-220Informations de copyright
Copyright © 2021 JCBNCopyright © 2021 JCBN.
Déclaration de conflit d'intérêts
No potential conflicts of interest were disclosed.
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