AGE-RAGE Stress and Coronary Artery Disease.
AGE–RAGE stress
advanced glycation end products (AGE)
atherosclerosis
atherosclerotic plaque rupture
cell receptor for AGE
coronary artery disease (CAD)
soluble receptors AGE
treatment modalities for AGE-RAGE stress-induced CAD
Journal
The International journal of angiology : official publication of the International College of Angiology, Inc
ISSN: 1061-1711
Titre abrégé: Int J Angiol
Pays: United States
ID NLM: 9504821
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
25
5
2021
Statut:
ppublish
Résumé
Coronary artery atherosclerosis and atherosclerotic plaque rupture cause coronary artery disease (CAD). Advanced glycation end products (AGE) and its cell receptor RAGE, and soluble receptor (sRAGE) and endogenous secretory RAGE (esRAGE) may be involved in the development of atherosclerosis. AGE and its interaction with RAGE are atherogenic, while sRAGE and esRAGE have antiatherogenic effects. AGE-RAGE stress is a ratio of AGE/sRAGE. A high AGE-RAGE stress results in development and progression of CAD and vice-versa. AGE levels in serum and skin, AGE/sRAGE in patients with CAD, and expression of RAGE in animal model of atherosclerosis were higher, while serum levels of esRAGE were lower in patients with CAD compared with controls. Serum levels of sRAGE in CAD patients were contradictory, increased or decreased. This contradictory data may be due to type of patients used, because the sRAGE levels are elevated in diabetics and end-stage renal disease. AGE/sRAGE ratio is elevated in patients with reduced or elevated levels of serum sRAGE. It is to stress that AGE, RAGE, sRAGE, or esRAGE individually cannot serve as universal biomarker. AGE and sRAGE should be measured simultaneously to assess the AGE-RAGE stress. The treatment of CAD should be targeted at reduction in AGE levels, prevention of AGE formation, degradation of AGE in vivo, suppression of RAGE expression, blockade of RAGE, elevation of sRAGE, and use of antioxidants. In conclusion, AGE-RAGE stress would initiate the development and progression of atherosclerosis. Treatment modalities would prevent, regress, and slow the progression of CAD.
Identifiants
pubmed: 34025091
doi: 10.1055/s-0040-1721813
pii: 200105
pmc: PMC8128491
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
4-14Informations de copyright
International College of Angiology. This article is published by Thieme.
Déclaration de conflit d'intérêts
Conflict of Interest None declared.
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