Purinergic P2 Receptors: Novel Mediators of Mechanotransduction.
cellular mechanotransduction
mechanical stress
mechanoreceptors
nucleotides
purinergic P2 receptors
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
02
2021
accepted:
26
04
2021
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
25
5
2021
Statut:
epublish
Résumé
Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial role in cellular mechanotransduction. Thus, information on the specific mechanism of P2 receptor-mediated mechanotransduction would be valuable. In this review, we focus on purinergic P2 receptor signaling pathways and describe in detail the interaction of P2 receptors with other mechanosensitive molecules, including transient receptor potential channels, integrins, caveolae-associated proteins and hemichannels. In addition, we review the activation of purinergic P2 receptors and the role of various P2 receptors in the regulation of various pathophysiological processes induced by mechanical stimuli.
Identifiants
pubmed: 34025431
doi: 10.3389/fphar.2021.671809
pii: 671809
pmc: PMC8138185
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
671809Informations de copyright
Copyright © 2021 Kong, Quan, Tian, Zhou and Liu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Biomed Res Int. 2014;2014:830374
pubmed: 24829920
Sci Rep. 2018 Jan 9;8(1):197
pubmed: 29317663
Adv Mater. 2018 Apr;30(17):e1705673
pubmed: 29543348
Bone Res. 2020 Jun 8;8:23
pubmed: 32550039
Nat Cell Biol. 2015 Jul;17(7):943-52
pubmed: 26098574
Annu Rev Biomed Eng. 2019 Jun 4;21:443-468
pubmed: 30916994
Neurogastroenterol Motil. 2014 Feb;26(2):237-46
pubmed: 24188286
Front Pharmacol. 2019 Nov 06;10:1304
pubmed: 31780935
J Pharmacol Sci. 2012;120(4):296-304
pubmed: 23196902
PLoS One. 2014 Aug 29;9(8):e106269
pubmed: 25170954
J Gen Physiol. 2018 Jan 2;150(1):19-39
pubmed: 29233884
EMBO J. 2008 Dec 3;27(23):3104-15
pubmed: 19008857
Br J Pharmacol. 2020 Jun;177(11):2413-2433
pubmed: 32037507
Nature. 2020 Nov;587(7835):567-576
pubmed: 33239794
Tissue Eng Part A. 2016 Jun;22(11-12):831-9
pubmed: 27137792
Sci Rep. 2017 Apr 10;7(1):771
pubmed: 28396595
Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1598-606
pubmed: 27255725
Methods Mol Biol. 2016;1437:203-11
pubmed: 27207297
J Endocrinol. 2017 Jun;233(3):341-356
pubmed: 28420708
Mol Cell Biol. 2019 Jul 29;39(16):
pubmed: 31160493
Elife. 2020 Feb 12;9:
pubmed: 32048993
FASEB J. 2020 Sep;34(9):12785-12804
pubmed: 32744386
J Orthop Res. 2017 Jun;35(6):1195-1202
pubmed: 26945892
J Physiol. 2015 Dec 1;593(23):5091-109
pubmed: 26377030
Digestion. 2020;101(1):6-11
pubmed: 31770754
Biomech Model Mechanobiol. 2015 Oct;14(5):979-93
pubmed: 25577546
ACS Pharmacol Transl Sci. 2020 Feb 21;3(2):171-178
pubmed: 32296760
Cells. 2020 Jan 28;9(2):
pubmed: 32013022
Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1477-H1485
pubmed: 30141983
FEBS Lett. 2015 Jan 30;589(3):310-8
pubmed: 25542352
Chem Rev. 2017 Jun 14;117(11):7457-7477
pubmed: 28211677
Nat Commun. 2020 Oct 21;11(1):5319
pubmed: 33087700
Biomolecules. 2019 Oct 18;9(10):
pubmed: 31635212
Am J Physiol Cell Physiol. 2015 Jan 1;308(1):C41-50
pubmed: 25318104
Nat Rev Cancer. 2018 Oct;18(10):601-618
pubmed: 30006588
J Periodontal Res. 2011 Oct;46(5):607-15
pubmed: 21615411
J Comp Neurol. 2004 Jan 26;469(1):16-36
pubmed: 14689471
FEBS Open Bio. 2020 Aug;10(8):1612-1623
pubmed: 32592329
Pharmacol Rev. 2011 Sep;63(3):641-83
pubmed: 21737531
J Biol Chem. 2014 Jun 6;289(23):16565-75
pubmed: 24759099
J Cell Biol. 2016 Nov 21;215(4):445-456
pubmed: 27872252
Cell Rep. 2019 Oct 1;29(1):1-12
pubmed: 31577940
J Cell Mol Med. 2018 Apr;22(4):2319-2328
pubmed: 29392898
Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G647-57
pubmed: 15331354
J Biol Chem. 2016 Jun 3;291(23):12208-22
pubmed: 27129210
Trends Cell Biol. 2020 Jan;30(1):49-59
pubmed: 31744661
J Clin Invest. 2015 Aug 3;125(8):3077-86
pubmed: 26168216
Elife. 2018 Jan 16;7:
pubmed: 29336303
J Cell Sci. 2014 Oct 1;127(Pt 19):4159-71
pubmed: 25097230
Cell Mol Life Sci. 2017 Feb;74(4):731-746
pubmed: 27652381
PLoS One. 2016 May 09;11(5):e0155107
pubmed: 27159053
Autophagy. 2017 Feb;13(2):404-422
pubmed: 28085543
BMC Genet. 2015 Jun 26;16:71
pubmed: 26112043
Int J Mol Sci. 2020 Apr 15;21(8):
pubmed: 32326617
Trends Mol Med. 2018 Dec;24(12):1036-1053
pubmed: 30424929
Pharmacol Rev. 2019 Jul;71(3):345-382
pubmed: 31235653
Gastroenterology. 2009 Dec;137(6):2096-104
pubmed: 19549524
J Orthop Res. 2018 Feb;36(2):642-652
pubmed: 29087614
Front Neurosci. 2016 Dec 19;10:564
pubmed: 28066160
Curr Osteoporos Rep. 2015 Apr;13(2):67-72
pubmed: 25616771
Br J Pharmacol. 2021 Feb;178(3):489-514
pubmed: 33125712
Int J Mol Sci. 2018 Nov 14;19(11):
pubmed: 30441872
Front Physiol. 2013 Oct 16;4:292
pubmed: 24137132
Purinergic Signal. 2019 Jun;15(2):155-166
pubmed: 31016551
J Orthop Res. 2010 Apr;28(4):510-5
pubmed: 19890993
Biophys J. 2018 Nov 20;115(10):2003-2013
pubmed: 30389091
Biochem Biophys Res Commun. 2015 Apr 24;460(1):22-5
pubmed: 25998730
Ann N Y Acad Sci. 2019 Apr;1442(1):79-90
pubmed: 29952014
Biomaterials. 2021 Jan;267:120497
pubmed: 33129187
J Bone Miner Res. 2013 Jun;28(6):1446-56
pubmed: 23362109
Stem Cell Res Ther. 2019 Nov 27;10(1):349
pubmed: 31775893
Cardiovasc Res. 2018 Feb 1;114(2):324-335
pubmed: 29126223
J Comp Neurol. 2004 Jan 26;469(1):1-15
pubmed: 14689470