XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent
ALD
IAP
alcohol-associated liver disease
alcoholic hepatitis
apoptosis
scRNA sequencing
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
02
2021
accepted:
31
03
2021
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
25
5
2021
Statut:
epublish
Résumé
Alcohol-associated liver disease (ALD) has been recognized as the most common cause of advanced liver disease worldwide, though mechanisms of pathogenesis remain incompletely understood. The X-linked inhibitor of apoptosis (XIAP) protein was originally described as an anti-apoptotic protein that directly binds and inhibits caspases-3, 7, and 9. Here, we investigated the function of XIAP in hepatocytes
Identifiants
pubmed: 34025452
doi: 10.3389/fphys.2021.664222
pmc: PMC8138467
doi:
Types de publication
Journal Article
Langues
eng
Pagination
664222Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK084567
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK111378
Pays : United States
Informations de copyright
Copyright © 2021 He, Sehrawat, Verma, Navarro-Corcuera, Sidhu, Mauer, Luo, Katsumi, Chen, Shah, Arab, Cao, Kashkar, Gores, Malhi and Shah.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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