Immunomodulation of T Helper Cells by Tumor Microenvironment in Oral Cancer Is Associated With CCR8 Expression and Rapid Membrane Vitamin D Signaling Pathway.
Adult
Aged
Aged, 80 and over
Female
Gene Expression Regulation, Neoplastic
/ immunology
Humans
Immunomodulation
Male
Middle Aged
Mouth Neoplasms
/ immunology
Neoplasm Proteins
/ immunology
Receptors, CCR8
/ immunology
Signal Transduction
/ immunology
Squamous Cell Carcinoma of Head and Neck
/ immunology
T-Lymphocytes, Regulatory
/ immunology
Th2 Cells
/ immunology
Tumor Microenvironment
/ immunology
Vitamin D
/ immunology
CCR8
Th-like Tregs
cancer immunology
immunomodulation
oral cancer
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
12
2020
accepted:
22
04
2021
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
24
9
2021
Statut:
epublish
Résumé
The immune system plays a key role in the protective response against oral cancer; however, the tumor microenvironment (TME) impairs this anti-cancer response by modulating T helper (Th) responses and promoting an anti-inflammatory environment. Regulatory T cells (Tregs) and Th2 effector cells (Teff) are associated with poor prognosis in oral squamous cell carcinoma (OSCC). However, the main immunomodulatory mechanisms associated with the enrichment of these subsets in OSCC remain unknown. We characterized Th-like lineages in Tregs and Teff and evaluated immunomodulatory changes induced by the TME in OSCC. Our phenotypic data revealed a higher distribution of tumour-infiltrating CCR8
Identifiants
pubmed: 34025655
doi: 10.3389/fimmu.2021.643298
pmc: PMC8137990
doi:
Substances chimiques
CCR8 protein, human
0
Neoplasm Proteins
0
Receptors, CCR8
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
643298Informations de copyright
Copyright © 2021 Fraga, Yáñez, Sherman, Llerena, Hernandez, Nourdin, Álvarez, Urrizola, Rivera, Lamperti, Nova, Castro, Zambrano, Cifuentes, Campos, Moya, Pastor, Nuñez, Gatica, Figueroa, Zúñiga, Salomón, Cerda, Puentes, Labarca, Vidal, McGregor and Nova-Lamperti.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
PLoS One. 2018 Apr 17;13(4):e0196034
pubmed: 29664967
Int J Oncol. 2017 Jan;50(1):41-48
pubmed: 27922697
Blood. 2013 Aug 1;122(5):825-36
pubmed: 23798714
Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24527-24532
pubmed: 31748273
Hum Immunol. 2018 Jun;79(6):439-445
pubmed: 29522785
Anal Chem. 2017 Sep 5;89(17):9048-9055
pubmed: 28763190
Cancer Cell. 2017 Mar 13;31(3):311-325
pubmed: 28292435
Cell Oncol (Dordr). 2012 Oct;35(5):335-43
pubmed: 22956260
J Biol Chem. 2010 Nov 19;285(47):37041-50
pubmed: 20843786
Immunology. 2019 Jul;157(3):232-247
pubmed: 31087644
Trends Genet. 1993 Apr;9(4):138-41
pubmed: 8516849
Immunol Rev. 2008 Aug;224:141-65
pubmed: 18759925
Endocrinology. 2020 Apr 1;161(4):
pubmed: 31995166
J Immunol. 2015 Jul 1;195(1):96-104
pubmed: 26002980
Cell Death Dis. 2015 Jun 18;6:e1792
pubmed: 26086965
J Craniomaxillofac Surg. 2019 Jan;47(1):33-40
pubmed: 30466788
Anal Chem. 2002 Oct 15;74(20):5383-92
pubmed: 12403597
J Pharm Bioallied Sci. 2016 Oct;8(Suppl 1):S8-S12
pubmed: 27829737
Jpn Dent Sci Rev. 2019 Nov;55(1):113-120
pubmed: 31660091
BMC Cancer. 2020 Jul 8;20(1):632
pubmed: 32641093
Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6086-6091
pubmed: 28533380
Arch Oral Biol. 2019 Aug;104:46-51
pubmed: 31170531
Oncotarget. 2017 Aug 3;8(39):66178-66194
pubmed: 29029502
Cell Rep. 2017 Jul 18;20(3):757-770
pubmed: 28723576
Cancer Immunol Immunother. 2010 Jun;59(6):819-28
pubmed: 20012605
Genome Biol. 2014;15(12):550
pubmed: 25516281
Nat Rev Clin Oncol. 2018 Oct;15(10):617-638
pubmed: 29795272
J Oral Pathol Med. 2011 Sep;40(8):636-42
pubmed: 21352381
PLoS One. 2014 Aug 25;9(8):e103975
pubmed: 25153698
J Clin Invest. 2015 May;125(5):2046-58
pubmed: 25866972
Adv Immunol. 2018;138:35-70
pubmed: 29731006
Immunity. 2014 Apr 17;40(4):569-81
pubmed: 24745333
JCI Insight. 2018 Jul 26;3(14):
pubmed: 30046006
Immunity. 2016 Nov 15;45(5):1122-1134
pubmed: 27851913
Sci Rep. 2020 Jun 16;10(1):9705
pubmed: 32546692
Pathol Oncol Res. 2018 Jul;24(3):497-505
pubmed: 28669079
Nat Immunol. 2010 Apr;11(4):344-9
pubmed: 20208539
Mol Cell Proteomics. 2018 Dec;17(12):2534-2545
pubmed: 30385480
Immunol Invest. 2003 Feb;32(1-2):17-30
pubmed: 12722939
J Exp Med. 2013 Sep 23;210(10):1889-98
pubmed: 23999500
PLoS One. 2016 Jan 08;11(1):e0146530
pubmed: 26745629
Int J Environ Res Public Health. 2020 May 02;17(9):
pubmed: 32370133
Anal Cell Pathol (Amst). 2020 Jan 8;2020:6283796
pubmed: 32377504
Bioinformatics. 2016 Oct 1;32(19):3047-8
pubmed: 27312411
Clin Dev Immunol. 2010;2010:701657
pubmed: 21437225
J Oral Pathol Med. 2018 Feb;47(2):136-143
pubmed: 29108105
Endocrinology. 2013 Oct;154(10):3864-76
pubmed: 23861370
Cancer Res. 2018 Sep 15;78(18):5340-5348
pubmed: 30026324
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
J Mol Histol. 2011 Apr;42(2):175-80
pubmed: 21442287
Cell Commun Signal. 2020 Apr 7;18(1):59
pubmed: 32264958
Cancer Epidemiol Biomarkers Prev. 2019 Mar;28(3):546-554
pubmed: 30487133
J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):48-56
pubmed: 22484374
J Surg Oncol. 2017 Dec;116(8):1103-1113
pubmed: 28833201
Anal Chem. 2003 Sep 1;75(17):4646-58
pubmed: 14632076
Am J Cancer Res. 2020 Jan 01;10(1):1-11
pubmed: 32064150
Rev Med Interne. 2008 Jul;29(7):606-8
pubmed: 18255200
Eur J Immunol. 1997 Dec;27(12):3526-31
pubmed: 9464843
Cancer Sci. 2017 Aug;108(8):1584-1593
pubmed: 28574664
J Transl Med. 2014 Jul 21;12:208
pubmed: 25048361
Periodontol 2000. 2011 Oct;57(1):19-37
pubmed: 21781177
Arch Oral Biol. 2016 Jan;61:28-35
pubmed: 26513679
Int J Oral Maxillofac Surg. 2019 Oct;48(10):1279-1288
pubmed: 31053518
J Clin Endocrinol Metab. 2019 May 1;104(5):1735-1752
pubmed: 30517676
Exp Ther Med. 2019 Sep;18(3):2187-2193
pubmed: 31452709
J Immunol. 2006 Nov 15;177(10):6940-51
pubmed: 17082609
Mol Cancer. 2019 Jan 15;18(1):10
pubmed: 30646912
J Immunother Cancer. 2020 Sep;8(2):
pubmed: 32900861
J Cell Biochem. 2003 Aug 1;89(5):922-32
pubmed: 12874827