Sensing Acute Cellular Rejection in Liver Transplant Patients Using Liver-Derived Extracellular Particles: A Prospective, Observational Study.
Adult
Aged
Annexin A5
/ blood
Asialoglycoprotein Receptor
/ blood
Biomarkers
/ blood
Cells, Cultured
Cytokine Receptor gp130
/ blood
Female
Graft Rejection
/ blood
Hepatocytes
/ immunology
Humans
Liquid Biopsy
/ methods
Liver
/ pathology
Liver Transplantation
/ adverse effects
Male
Middle Aged
Prospective Studies
Sensitivity and Specificity
Transplantation, Homologous
/ adverse effects
FlowSOM
acute cellular liver transplant rejection
extracellular particles (EP)
liquid biopsy
liver transplantation
sensitivity and specificity
t-SNE (t-Distributed Stochastic Neighbor Embedding)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
12
2020
accepted:
20
04
2021
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
7
10
2021
Statut:
epublish
Résumé
Acute cellular rejection (ACR) after liver transplantation (LT) goes along with allograft dysfunction, which is diagnosed by liver biopsy and concomitant histological analysis, representing the gold standard in clinical practice. Yet, liver biopsies are invasive, costly, time-intensive and require expert knowledge. Herein we present substantial evidence that blood plasma residing peripheral liver-derived extracellular particles (EP) could be employed to diagnose ACR non-invasively.
Identifiants
pubmed: 34025656
doi: 10.3389/fimmu.2021.647900
pmc: PMC8131523
doi:
Substances chimiques
ANXA5 protein, human
0
ASGR1 protein, human
0
Annexin A5
0
Asialoglycoprotein Receptor
0
Biomarkers
0
IL6ST protein, human
0
Cytokine Receptor gp130
133483-10-0
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
647900Informations de copyright
Copyright © 2021 Kamali, Schmelzle, Kamali, Brunnbauer, Splith, Leder, Berndt, Hillebrandt, Raschzok, Feldbrügge, Felsenstein, Gaßner, Ritschl, Lurje, Schöning, Benzing, Pratschke and Krenzien.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Hepatology. 1992 Apr;15(4):702-6
pubmed: 1372583
Transpl Int. 2016 Sep;29(9):961-73
pubmed: 26714264
HPB (Oxford). 2015 Feb;17(2):168-75
pubmed: 25263399
J Histochem Cytochem. 2013 Dec;61(12):901-9
pubmed: 23979840
Eur Heart J. 1997 Jun;18(6):1024-9
pubmed: 9183597
Eur J Haematol. 2009 Sep;83(3):220-9
pubmed: 19456851
J Pathol. 2008 Jan;214(2):149-60
pubmed: 18161752
Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):1054-8
pubmed: 22328775
J Gastroenterol. 1994 Feb;29(1):24-30
pubmed: 7515307
Nature. 2009 Jan 8;457(7226):200-4
pubmed: 19020503
Transplant Direct. 2017 Feb 07;3(3):e131
pubmed: 28361115
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
J Biol Chem. 1997 Dec 5;272(49):30741-7
pubmed: 9388212
Transpl Immunol. 2014 Aug;31(2):60-4
pubmed: 25008980
BMJ. 2015 Oct 28;351:h5527
pubmed: 26511519
Liver Transpl. 2016 Aug;22(8):1136-42
pubmed: 27082951
J Hepatol. 2013 Jun;58(6):1194-200
pubmed: 23376361
Nat Biotechnol. 2013 Jun;31(6):545-52
pubmed: 23685480
Thromb Res. 2015 May;135(5):1000-6
pubmed: 25726425
Sci Rep. 2019 Apr 25;9(1):6542
pubmed: 31024069
Hepatology. 2011 Jan;53(1):230-42
pubmed: 20979056
J Exp Med. 1987 Oct 1;166(4):1132-7
pubmed: 3309124
Transplantation. 2017 Jan;101(1):32-44
pubmed: 27547870
Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):15-26
pubmed: 21160064
Gastroenterology. 1996 Jun;110(6):1854-62
pubmed: 8964411
Crit Care. 2011;15(5):R251
pubmed: 22027379
Nat Struct Mol Biol. 2020 Jan;27(1):62-70
pubmed: 31873305
Transplantation. 1994 Apr 15;57(7):1037-41
pubmed: 8165699
J Clin Med. 2020 May 20;9(5):
pubmed: 32443763
Cytometry A. 2020 Jun;97(6):592-601
pubmed: 32476280
J Hepatol. 2017 Aug;67(2):282-292
pubmed: 28267620
Biochim Biophys Acta. 2016 Jun;1862(6):1111-21
pubmed: 26912412
Cell Immunol. 2007 Jun;247(2):103-10
pubmed: 17900549
Cytometry A. 2015 Jul;87(7):636-45
pubmed: 25573116
J Heart Lung Transplant. 2008 Jan;27(1):38-45
pubmed: 18187085
Biomarkers. 2018 Feb;23(1):25-32
pubmed: 28303731
Auto Immun Highlights. 2012 Oct 30;3(3):119-25
pubmed: 26000135
Toxicol Sci. 2014 Jan;137(1):91-101
pubmed: 24097668
Transplantation. 2013 Jan 15;95(1):63-9
pubmed: 23232366
PLoS One. 2018 Apr 12;13(4):e0195262
pubmed: 29649247
Thromb Haemost. 2010 May;103(5):1044-52
pubmed: 20390225
Front Immunol. 2019 Apr 11;10:758
pubmed: 31031758
Transplantation. 2015 Nov;99(11):2258-68
pubmed: 26244716
Exp Clin Transplant. 2018 Oct;16(5):554-561
pubmed: 29633929
Transplantation. 2018 Nov;102(11):1795-1814
pubmed: 30028786
Hepatology. 1991 Dec;14(6):1063-5
pubmed: 1959854
J Extracell Vesicles. 2014 Feb 04;3:
pubmed: 24511371
Pflugers Arch. 2007 Feb;453(5):601-10
pubmed: 16622704