The association of endothelin-1 gene polymorphism and its plasma levels with hypertension and coronary atherosclerosis.
SNP
atherosclerosis
endothelin-1
hypertension
rs1046872
rs5370
Journal
Archives of medical science : AMS
ISSN: 1734-1922
Titre abrégé: Arch Med Sci
Pays: Poland
ID NLM: 101258257
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
01
2018
accepted:
25
05
2018
entrez:
24
5
2021
pubmed:
22
7
2019
medline:
22
7
2019
Statut:
epublish
Résumé
Endothelin-1 (ET-1) is the most potent among all vasoconstrictors, and its association with cardiovascular diseases has been reported before. Our aim was to investigate the association of ET-1 plasma level and its gene polymorphisms ( This study was carried out on 128 women and 132 men, who were divided into 4 groups: hypertensive without atherosclerosis (H+A-); hypertensive with atherosclerosis (H+A+); non-hypertensive with atherosclerosis (H-A+); and non-hypertensive without atherosclerosis (control group). Endothelin-1 plasma levels were measured by ELISA, and gene polymorphisms were detected by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) methods. Coronary artery diseases (CAD) were then defined based on angiography data. The ET-1 plasma level was significantly higher in the H+A+ group in comparison with the other groups, especially H+A-. Comparing people with CA and those without it, the highest frequency level of the T allele of Endothelin-1 plasma level shows a direct association with the risk of CA development. The T allele of
Identifiants
pubmed: 34025830
doi: 10.5114/aoms.2019.86770
pii: 91675
pmc: PMC8130481
doi:
Types de publication
Journal Article
Langues
eng
Pagination
613-620Informations de copyright
Copyright: © 2019 Termedia & Banach.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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