Rationalising animal research synthesis in orthopaedic literature.
Animal research
Evidence synthesis
Meta-analysis
Orthopaedics
in vivo
Journal
World journal of methodology
ISSN: 2222-0682
Titre abrégé: World J Methodol
Pays: United States
ID NLM: 101628739
Informations de publication
Date de publication:
20 May 2021
20 May 2021
Historique:
received:
02
01
2021
revised:
05
02
2021
accepted:
12
03
2021
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
25
5
2021
Statut:
epublish
Résumé
Systematic reviews in orthopaedic literature are frequently criticised for offering inconsistent conclusions. On top of that, high-quality randomized human evidence on crucial orthopaedic topics is more often than not lacking. In this situation, pooling animal literature could offer an excellent insight into unanswered critical clinical questions, thus potentially improving healthcare. In this paper, we sought to present the rationale and basic principles governing meta-analysis of animal research. More specifically, we elaborated on the available evidence-based methods to achieve a scientifically sound animal data synthesis. In addition, we discussed result interpretation, strength of recommendations and clinical implications based on the results of these meta-analytic modalities.
Identifiants
pubmed: 34026580
doi: 10.5662/wjm.v11.i3.75
pmc: PMC8127423
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
75-80Informations de copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
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